Thrombospondin 4
Thrombospondin-4 is a protein that in humans is encoded by the THBS4 gene.[5][6]
The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000113296 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021702 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Lawler J, McHenry K, Duquette M, Derick L (Mar 1995). "Characterization of human thrombospondin-4". J Biol Chem. 270 (6): 2809–14. PMID 7852353. doi:10.1074/jbc.270.6.2809.
- 1 2 "Entrez Gene: THBS4 thrombospondin 4".
Further reading
- Arber S, Caroni P (1996). "Thrombospondin-4, an extracellular matrix protein expressed in the developing and adult nervous system promotes neurite outgrowth.". J. Cell Biol. 131 (4): 1083–94. PMC 2200004
. PMID 7490284. doi:10.1083/jcb.131.4.1083. - Lawler J, Duquette M, Urry L, et al. (1993). "The evolution of the thrombospondin gene family.". J. Mol. Evol. 36 (6): 509–16. PMID 8350346. doi:10.1007/BF00556355.
- Lawler J, Duquette M, Whittaker CA, et al. (1993). "Identification and characterization of thrombospondin-4, a new member of the thrombospondin gene family.". J. Cell Biol. 120 (4): 1059–67. PMC 2200072 . PMID 8432726. doi:10.1083/jcb.120.4.1059.
- Newton G, Weremowicz S, Morton CC, et al. (2000). "The thrombospondin-4 gene.". Mamm. Genome. 10 (10): 1010–6. PMID 10501972. doi:10.1007/s003359901149.
- Carron JA, Hiscott P, Hagan S, et al. (2001). "Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4.". Int. J. Biochem. Cell Biol. 32 (11-12): 1137–42. PMID 11137453. doi:10.1016/S1357-2725(00)00065-0.
- Luo J, Dunn T, Ewing C, et al. (2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis.". Prostate. 51 (3): 189–200. PMID 11967953. doi:10.1002/pros.10087.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Congote LF, Difalco MR, Gibbs BF (2004). "The C-terminal peptide of thrombospondin-4 stimulates erythroid cell proliferation.". Biochem. Biophys. Res. Commun. 324 (2): 673–8. PMID 15474480. doi:10.1016/j.bbrc.2004.09.107.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- van Doorn R, Zoutman WH, Dijkman R, et al. (2005). "Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73.". J. Clin. Oncol. 23 (17): 3886–96. PMID 15897551. doi:10.1200/JCO.2005.11.353.
- Stenina OI, Ustinov V, Krukovets I, et al. (2006). "Polymorphisms A387P in thrombospondin-4 and N700S in thrombospondin-1 perturb calcium binding sites.". FASEB J. 19 (13): 1893–5. PMID 16148025. doi:10.1096/fj.05-3712fje.
- Misenheimer TM, Mosher DF (2006). "Biophysical characterization of the signature domains of thrombospondin-4 and thrombospondin-2.". J. Biol. Chem. 280 (50): 41229–35. PMC 2219889 . PMID 16246837. doi:10.1074/jbc.M504696200.
- Cui J, Randell E, Renouf J, et al. (2006). "Thrombospondin-4 1186G>C (A387P) is a sex-dependent risk factor for myocardial infarction: a large replication study with increased sample size from the same population.". Am. Heart J. 152 (3): 543.e1–5. PMID 16923428. doi:10.1016/j.ahj.2006.06.002.
- Cáceres M, Suwyn C, Maddox M, et al. (2007). "Increased cortical expression of two synaptogenic thrombospondins in human brain evolution.". Cereb. Cortex. 17 (10): 2312–21. PMID 17182969. doi:10.1093/cercor/bhl140.
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