TGF beta 2

TGFB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TFG, 2TGI, 4KXZ
Identifiers
Aliases	TGFB2, LDS4, TGF-beta2, transforming growth factor beta 2, G-TSF
External IDs	OMIM: 190220 MGI: 98726 HomoloGene: 2432 GeneCards: TGFB2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band No data available Start 218,346,235 bp[1] End 218,444,619 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band No data available Start 186,622,792 bp[2] End 186,705,989 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • type II transforming growth factor beta receptor binding • receptor binding • type III transforming growth factor beta receptor binding • cytokine activity • signal transducer, downstream of receptor, with serine/threonine kinase activity • transforming growth factor beta receptor binding • growth factor activity • protein homodimerization activity • amyloid-beta binding • protein binding • protein heterodimerization activity Cellular component • extracellular region • extracellular matrix • platelet alpha granule lumen • extracellular space • axon • neuronal cell body Biological process • eye development • regulation of transforming growth factor beta2 production • embryo development • response to progesterone • cell death • cardioblast differentiation • positive regulation of integrin biosynthetic process • protein phosphorylation • positive regulation of heart contraction • positive regulation of neuron apoptotic process • angiogenesis • negative regulation of epithelial cell proliferation • uterine wall breakdown • negative regulation of alkaline phosphatase activity • negative regulation of macrophage cytokine production • positive regulation of cell adhesion mediated by integrin • cell proliferation • transforming growth factor beta receptor signaling pathway • negative regulation of cell proliferation • positive regulation of stress-activated MAPK cascade • cell-cell junction organization • SMAD protein signal transduction • extrinsic apoptotic signaling pathway • SMAD protein import into nucleus • collagen fibril organization • positive regulation of epithelial cell migration • neutrophil chemotaxis • cell growth • positive regulation of cell growth • response to wounding • negative regulation of cell growth • positive regulation of cardioblast differentiation • glial cell migration • wound healing • positive regulation of ossification • cardiac muscle cell proliferation • positive regulation of epithelial to mesenchymal transition • odontogenesis • positive regulation of timing of catagen • positive regulation of immune response • regulation of complement-dependent cytotoxicity • positive regulation of protein secretion • epithelial to mesenchymal transition • catagen • embryonic digestive tract development • response to hypoxia • cell-cell signaling • positive regulation of pathway-restricted SMAD protein phosphorylation • heart morphogenesis • platelet degranulation • salivary gland morphogenesis • generation of neurons • negative regulation of immune response • cell cycle arrest • cell morphogenesis • positive regulation of cell proliferation • positive regulation of phosphatidylinositol 3-kinase signaling • cell migration • activation of protein kinase activity • positive regulation of cell division • response to drug • cardiac epithelial to mesenchymal transition • signal transduction by protein phosphorylation • BMP signaling pathway • cell development • skeletal system development • kidney development • neural tube closure • hair follicle development • outflow tract septum morphogenesis • membranous septum morphogenesis • heart valve morphogenesis • atrioventricular valve morphogenesis • pulmonary valve morphogenesis • endocardial cushion morphogenesis • cardiac right ventricle morphogenesis • ventricular trabecula myocardium morphogenesis • endocardial cushion fusion • atrial septum primum morphogenesis • neural retina development • heart development • male gonad development • hemopoiesis • embryonic limb morphogenesis • hair follicle morphogenesis • ascending aorta morphogenesis • dopamine biosynthetic process • positive regulation of cell cycle • negative regulation of Ras protein signal transduction • somatic stem cell division • neuron development • inner ear development • palate development • uterus development • pathway-restricted SMAD protein phosphorylation • ventricular septum morphogenesis • atrial septum morphogenesis • pharyngeal arch artery morphogenesis • regulation of apoptotic process involved in outflow tract morphogenesis • substantia propria of cornea development • cranial skeletal system development • negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7042	21808
Ensembl	ENSG00000092969	ENSMUSG00000039239
UniProt	P61812	P27090
RefSeq (mRNA)	NM_003238 NM_001135599	NM_009367 NM_001329107
RefSeq (protein)	NP_001129071 NP_003229	NP_001316036 NP_033393
Location (UCSC)	Chr 1: 218.35 – 218.44 Mb	Chr 1: 186.62 – 186.71 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene.

Further reading

1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000092969 - Ensembl, May 2017
2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039239 - Ensembl, May 2017
3. ↑ "Human PubMed Reference:". 
4. ↑ "Mouse PubMed Reference:".