TFB2M

Identifiers

TFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial

External IDs

MGI: 107937 HomoloGene: 7362 GeneCards: TFB2M

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	246,540,560 bp^[1]
Band	No data available	End	246,566,324 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	No data available	Start	179,528,055 bp^[2]
Band	No data available	End	179,546,267 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• methyltransferase activity • transferase activity • transcription cofactor activity • rRNA methyltransferase activity • rRNA (adenine-N6,N6-)-dimethyltransferase activity • RNA binding
Cellular component	• cell junction • mitochondrial nucleoid • mitochondrial matrix • mitochondrion
Biological process	• positive regulation of transcription, DNA-templated • rRNA processing • methylation • mitochondrion organization • regulation of transcription, DNA-templated • rRNA methylation • transcription, DNA-templated • transcription from mitochondrial promoter • transcription initiation from mitochondrial promoter • rRNA modification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


64216


15278

Ensembl


ENSG00000162851


ENSMUSG00000026492

UniProt


Q9H5Q4


Q3TL26

RefSeq (mRNA)


NM_022366


NM_008249 NM_001331054 NM_001331055

RefSeq (protein)


NP_071761


NP_001317983 NP_001317984 NP_032275

Location (UCSC)

Chr 1: 246.54 – 246.57 Mb

Chr 1: 179.53 – 179.55 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Dimethyladenosine transferase 2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162851 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026492 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: TFB2M transcription factor B2, mitochondrial".

Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA.". Nat. Genet. 31 (3): 289–94. PMID 12068295. doi:10.1038/ng909.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2.". Mamm. Genome. 14 (1): 1–6. PMID 12532263. doi:10.1007/s00335-002-2218-z.
McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity.". Mol. Cell. Biol. 23 (16): 5816–24. PMC 166325 . PMID 12897151. doi:10.1128/MCB.23.16.5816-5824.2003.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells.". EMBO J. 23 (23): 4606–14. PMC 533051 . PMID 15526033. doi:10.1038/sj.emboj.7600465.
Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.". Mol. Cell. Biol. 25 (4): 1354–66. PMC 548005 . PMID 15684387. doi:10.1128/MCB.25.4.1354-1366.2005.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727.
Cotney J, Shadel GS (2007). "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2.". J. Mol. Evol. 63 (5): 707–17. PMID 17031457. doi:10.1007/s00239-006-0075-1.
Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression.". Nucleic Acids Res. 35 (12): 4042–54. PMC 1919481 . PMID 17557812. doi:10.1093/nar/gkm424.

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TFB2M

References

Further reading