TERRA (biology)

TERRA in biology is an abbreviation for "TElomeric Repeat-containing RNA".[1] TERRA is RNA that is transcribed from telomeres — the repeating 6-nucleotide sequences that cap the ends of chromosomes. TERRA functions with shelterin to inhibit telomere lengthening by telomerase enzyme.[1] At least four factors contribute to telomere maintenance: telomerase, shelterin, TERRA and the CST Complex.[2]

TERRA can also regulate telomere length by increasing euchromatin formation.[3] On the other hand, nonsense-mediated decay factor enrichment at telomeres may exist to prevent TERRA inhibition of telomerase.[1] TERRA levels vary during the cell cycle, decreasing during S phase, and increasing in the transition from G2 phase to G1 phase.[3]

References

  1. 1 2 3 Luke B, Lingner J (2009). "TERRA: telomeric repeat-containing RNA". The EMBO Journal. 28 (17): 2503–2510. PMC 2722245 Freely accessible. PMID 19629047. doi:10.1038/emboj.2009.166.
  2. ↑ Giraud-Panis MJ, Teixeira MT, Géli V, Gilson E (2010). "CST meets shelterin to keep telomeres in check". Molecular Cell. 39 (5): 665–676. PMID 20832719. doi:10.1016/j.molcel.2010.08.024.
  3. 1 2 Wang C, Zhao L, Lu S (2015). "Role of TERRA in the regulation of telomere length". International Journal of Biological Sciences. 11 (3): 316–323. PMC 4323371 Freely accessible. PMID 25678850. doi:10.7150/ijbs.10528.


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