TCF12
Transcription factor 12 is a protein that in humans is encoded by the TCF12 gene.[5][6]
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]
Mutations in this gene have been associated to cases of coronal craniosynostosis (doi: 10.1038/ng.2531)
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000140262 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032228 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Zhang Y, Babin J, Feldhaus AL, Singh H, Sharp PA, Bina M (Oct 1991). "HTF4: a new human helix-loop-helix protein". Nucleic Acids Res. 19 (16): 4555. PMC 328652
. PMID 1886779. doi:10.1093/nar/19.16.4555. - 1 2 "Entrez Gene: TCF12 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)".
Further reading
- Bain G, Murre C (1998). "The role of E-proteins in B- and T-lymphocyte development.". Semin. Immunol. 10 (2): 143–53. PMID 9618760. doi:10.1006/smim.1998.0116.
- Hu JS, Olson EN, Kingston RE (1992). "HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.". Mol. Cell. Biol. 12 (3): 1031–42. PMC 369535 . PMID 1312219.
- Zhang Y, Bina M (1992). "The nucleotide sequence of the human transcription factor HTF4a cDNA.". DNA Seq. 2 (6): 397–403. PMID 1446075. doi:10.3109/10425179209020819.
- Zhang Y, Doyle K, Bina M (1992). "Interactions of HTF4 with E-box motifs in the long terminal repeat of human immunodeficiency virus type 1.". J. Virol. 66 (9): 5631–4. PMC 289128 . PMID 1501295.
- Sommer L, Hagenbüchle O, Wellauer PK, Strubin M (1992). "Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence.". Cell. 67 (5): 987–94. PMID 1720355. doi:10.1016/0092-8674(91)90371-5.
- Zhang Y, Flejter WL, Barcroft CL, et al. (1995). "Localization of the human HTF4 transcription factors 4 gene (TCF12) to chromosome 15q21.". Cytogenet. Cell Genet. 68 (3-4): 235–8. PMID 7842744. doi:10.1159/000133921.
- Doyle K, Zhang Y, Baer R, Bina M (1994). "Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins.". J. Biol. Chem. 269 (16): 12099–105. PMID 8163514.
- Langlands K, Yin X, Anand G, Prochownik EV (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.". J. Biol. Chem. 272 (32): 19785–93. PMID 9242638. doi:10.1074/jbc.272.32.19785.
- Goldfarb AN, Lewandowska K, Pennell CA (1998). "Identification of a highly conserved module in E proteins required for in vivo helix-loop-helix dimerization.". J. Biol. Chem. 273 (5): 2866–73. PMID 9446597. doi:10.1074/jbc.273.5.2866.
- Massari ME, Rivera RR, Voland JR, et al. (1998). "Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes.". Mol. Cell. Biol. 18 (6): 3130–9. PMC 108895 . PMID 9584154.
- Adell T, Gómez-Cuadrado A, Skoudy A, et al. (2000). "Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells.". Cell Growth Differ. 11 (3): 137–47. PMID 10768861.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
- Mandolesi G, Gargano S, Pennuto M, et al. (2002). "NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction.". FEBS Lett. 510 (1-2): 50–6. PMID 11755530. doi:10.1016/S0014-5793(01)03227-6.
- Knöfler M, Meinhardt G, Bauer S, et al. (2002). "Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains.". Biochem. J. 361 (Pt 3): 641–51. PMC 1222348 . PMID 11802795. doi:10.1042/0264-6021:3610641.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Tremblay M, Herblot S, Lecuyer E, Hoang T (2003). "Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.". J. Biol. Chem. 278 (15): 12680–7. PMID 12566462. doi:10.1074/jbc.M209870200.
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