TCEAL1
| TCEAL1 |
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| Identifiers |
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| Aliases | TCEAL1, SIIR, WEX9, p21, pp21, transcription elongation factor A like 1 |
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| External IDs | MGI: 2385317 HomoloGene: 3510 GeneCards: TCEAL1 |
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| Gene location (Human) |
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 | | Chr. | X chromosome (human)[1] |
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| | Band | No data available | Start | 103,628,704 bp[1] |
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| End | 103,630,953 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | X chromosome (mouse)[2] |
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| | Band | No data available | Start | 136,707,982 bp[2] |
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| End | 136,711,478 bp[2] |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | | |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr X: 103.63 – 103.63 Mb | Chr X: 136.71 – 136.71 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
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Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.[5][6][7]
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.[7]
References
Further reading
- Yeh CH, Zong WX, Shatkin AJ (1995). "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression". J. Biol. Chem. 270 (43): 25313–5. PMID 7592688. doi:10.1074/jbc.270.44.26558.
- Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR". Genomics. 56 (2): 217–20. PMID 10051408. doi:10.1006/geno.1998.5705.
- van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. PMID 10353443. doi:10.1007/s001090050365.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. PMC 2665286 . PMID 15772651. doi:10.1038/nature03440.
- Makino H, Tajiri T, Miyashita M, et al. (2005). "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis". Dis. Esophagus. 18 (1): 37–40. PMID 15773840. doi:10.1111/j.1442-2050.2005.00432.x.
- Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. PMID 16341674. doi:10.1007/s00335-005-0075-2.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
