TAF12

TAF12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H3O
Identifiers
Aliases	TAF12, TAF2J, TAFII20, TATA-box binding protein associated factor 12
External IDs	MGI: 1913714 HomoloGene: 68477 GeneCards: TAF12
Gene location (Human) Chr. Chromosome 1 (human)[1] Band No data available Start 28,589,323 bp[1] End 28,643,085 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band No data available Start 132,274,375 bp[2] End 132,295,766 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • transcription factor binding • protein binding • protein heterodimerization activity • RNA polymerase II activating transcription factor binding • TBP-class protein binding • histone acetyltransferase activity Cellular component • transcription factor TFTC complex • STAGA complex • transcription factor TFIID complex • nucleoplasm • PCAF complex • SAGA complex • nucleus Biological process • regulation of transcription, DNA-templated • transcription elongation from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • transcription from RNA polymerase II promoter • transcription, DNA-templated • DNA-templated transcription, initiation • transcription initiation from RNA polymerase II promoter • regulation of signal transduction by p53 class mediator • RNA polymerase II transcriptional preinitiation complex assembly • histone H3 acetylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6883	66464
Ensembl	ENSG00000120656	ENSMUSG00000028899
UniProt	Q16514	Q8VE65
RefSeq (mRNA)	NM_001135218 NM_005644	NM_025579
RefSeq (protein)	NP_001128690 NP_005635	NP_079855
Location (UCSC)	Chr 1: 28.59 – 28.64 Mb	Chr 1: 132.27 – 132.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.^[5][6]

Function

Control of transcription by RNA polymerase II involves the basal transcription machinery, which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes that are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached, whereas others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I.^[6]

Interactions

TAF12 has been shown to interact with TAF9^[7] and Transcription initiation protein SPT3 homolog.^[7]

References

Further reading