TADA2L

TADA2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTADA2A, ADA2, ADA2A, TADA2L, hADA2, KL04P, transcriptional adaptor 2A
External IDsMGI: 2144471 HomoloGene: 38834 GeneCards: TADA2A
Gene location (Human)
Chr.Chromosome 17 (human)[1]
BandNo data availableStart37,406,874 bp[1]
End37,479,730 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6871

217031

Ensembl

ENSG00000276234
ENSG00000277104

ENSMUSG00000018651

UniProt

O75478

Q8CHV6

RefSeq (mRNA)

NM_001166105
NM_001291918
NM_001488
NM_133439

NM_172562

RefSeq (protein)

NP_001159577
NP_001278847
NP_001479
NP_597683

NP_766150

Location (UCSC)Chr 17: 37.41 – 37.48 MbChr 17: 84.08 – 84.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional adapter 2-alpha is a protein that in humans is encoded by the TADA2A gene.[5][6]

Function

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different isoforms have been identified for this gene.[6]

Interactions

TADA2L has been shown to interact with GCN5L2,[7][8] TADA3L[9][10] and Myc.[11]

References

  1. 1 2 3 ENSG00000277104 GRCh38: Ensembl release 89: ENSG00000276234, ENSG00000277104 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018651 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (Feb 1996). "Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5". Molecular and Cellular Biology. 16 (2): 593–602. PMC 231038 Freely accessible. PMID 8552087. doi:10.1128/mcb.16.2.593.
  6. 1 2 "Entrez Gene: TADA2L transcriptional adaptor 2 (ADA2 homolog, yeast)-like".
  7. ↑ Barlev NA, Poltoratsky V, Owen-Hughes T, Ying C, Liu L, Workman JL, Berger SL (Mar 1998). "Repression of GCN5 histone acetyltransferase activity via bromodomain-mediated binding and phosphorylation by the Ku-DNA-dependent protein kinase complex". Molecular and Cellular Biology. 18 (3): 1349–58. PMC 108848 Freely accessible. PMID 9488450. doi:10.1128/mcb.18.3.1349.
  8. ↑ Wang L, Mizzen C, Ying C, Candau R, Barlev N, Brownell J, Allis CD, Berger SL (Jan 1997). "Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation". Molecular and Cellular Biology. 17 (1): 519–27. PMC 231776 Freely accessible. PMID 8972232. doi:10.1128/mcb.17.1.519.
  9. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
  10. ↑ Wang T, Kobayashi T, Takimoto R, Denes AE, Snyder EL, el-Deiry WS, Brachmann RK (Nov 2001). "hADA3 is required for p53 activity". The EMBO Journal. 20 (22): 6404–13. PMC 125723 Freely accessible. PMID 11707411. doi:10.1093/emboj/20.22.6404.
  11. ↑ Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. PMC 4031917 Freely accessible. PMID 12660246. doi:10.1074/jbc.M211795200.

Further reading

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