SV2A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4V11

Identifiers

Aliases

SV2A, SV2, synaptic vesicle glycoprotein 2A

External IDs

MGI: 1927139 HomoloGene: 32237 GeneCards: SV2A

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	149,903,318 bp^[1]
Band	No data available	End	149,917,882 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	No data available	Start	96,181,151 bp^[2]
Band	No data available	End	96,195,521 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transmembrane transporter activity • transporter activity • protein kinase binding • receptor activity
Cellular component	• membrane • synaptic vesicle • cell-cell junction • neuromuscular junction • plasma membrane • synapse • presynaptic active zone • terminal bouton • cell junction • endoplasmic reticulum • cytoplasmic vesicle • integral component of membrane • integral component of synaptic vesicle membrane • synaptic vesicle membrane • neuron projection • dendrite • neuronal cell body
Biological process	• cellular calcium ion homeostasis • transmembrane transport • neurotransmitter transport • regulation of gamma-aminobutyric acid secretion • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9900


64051

Ensembl


ENSG00000159164


ENSMUSG00000038486

UniProt


Q7L0J3


Q9JIS5

RefSeq (mRNA)


NM_014849 NM_001278719 NM_001328674 NM_001328675


NM_022030

RefSeq (protein)


NP_001265648 NP_001315603 NP_001315604 NP_055664


NP_071313

Location (UCSC)

Chr 1: 149.9 – 149.92 Mb

Chr 1: 96.18 – 96.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene.^[5]^[6]^[7] The protein is targeted by the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159164 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038486 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Bajjalieh SM, Peterson K, Linial M, Scheller RH (Mar 1993). "Brain contains two forms of synaptic vesicle protein 2". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2150–4. PMC 46043 . PMID 7681585. doi:10.1073/pnas.90.6.2150.
↑ Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM (Dec 1999). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 15268–73. PMC 24809 . PMID 10611374. doi:10.1073/pnas.96.26.15268.
↑ "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A".
↑ Ulloa CM, Towfigh A, Safdieh J (2009). "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatric Disease and Treatment. 5: 467–76. PMC 2747386 . PMID 19777068. doi:10.2147/ndt.s4844.

Bajjalieh SM, Peterson K, Shinghal R, Scheller RH (Aug 1992). "SV2, a brain synaptic vesicle protein homologous to bacterial transporters". Science. 257 (5074): 1271–3. PMID 1519064. doi:10.1126/science.1519064.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. PMID 9872452. doi:10.1093/dnares/5.5.277.
Son YJ, Scranton TW, Sunderland WJ, Baek SJ, Miner JH, Sanes JR, Carlson SS (Jan 2000). "The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface". The Journal of Biological Chemistry. 275 (1): 451–60. PMID 10617638. doi:10.1074/jbc.275.1.451.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B (Jun 2004). "The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam". Proceedings of the National Academy of Sciences of the United States of America. 101 (26): 9861–6. PMC 470764 . PMID 15210974. doi:10.1073/pnas.0308208101.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex". Journal of Proteome Research. 4 (2): 306–15. PMID 15822905. doi:10.1021/pr0498436.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. PMID 16303743. doi:10.1093/dnares/12.2.117.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.

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SV2A

See also

References

Further reading