Gem-associated protein 2
Gem-associated protein 2 (GEMIN2), also called survival of motor neuron protein-interacting protein 1 (SIP1), is a protein that in humans is encoded by the GEMIN2 gene.[3][4][5]
Interactions
Gem-associated protein 2 has been shown to interact with DDX20[6][7] and SMN1.[4][8][9]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Fischer U, Liu Q, Dreyfuss G (October 1997). "The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis". Cell. 90 (6): 1023–9. PMID 9323130. doi:10.1016/S0092-8674(00)80368-2.
- 1 2 Liu Q, Fischer U, Wang F, Dreyfuss G (October 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. PMID 9323129. doi:10.1016/S0092-8674(00)80367-0.
- ↑ "Entrez Gene: SIP1 survival of motor neuron protein interacting protein 1".
- ↑ Mourelatos, Zissimos; Dostie Josée; Paushkin Sergey; Sharma Anup; Charroux Bernard; Abel Linda; Rappsilber Juri; Mann Matthias; Dreyfuss Gideon (March 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. United States. 16 (6): 720–8. ISSN 0890-9369. PMC 155365
. PMID 11914277. doi:10.1101/gad.974702. - ↑ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. UNITED STATES. 147 (6): 1181–94. ISSN 0021-9525. PMC 2168095 . PMID 10601333. doi:10.1083/jcb.147.6.1181.
- ↑ Carnegie, Graeme K; Sleeman Judith E; Morrice Nick; Hastie C James; Peggie Mark W; Philp Amanda; Lamond Angus I; Cohen Patricia T W (May 2003). "Protein phosphatase 4 interacts with the Survival of motor neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. England. 116 (Pt 10): 1905–13. ISSN 0021-9533. PMID 12668731. doi:10.1242/jcs.00409.
- ↑ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. ENGLAND. 9 (13): 1977–86. ISSN 0964-6906. PMID 10942426. doi:10.1093/hmg/9.13.1977.
Further reading
- Wang Z, Wu X, Friedberg EC (1997). "Molecular mechanism of base excision repair of uracil-containing DNA in yeast cell-free extracts". J. Biol. Chem. 272 (38): 24064–71. PMID 9295360. doi:10.1074/jbc.272.38.24064.
- Zhang WJ, Wu JY (1998). "Sip1, a Novel RS Domain-Containing Protein Essential for Pre-mRNA Splicing". Mol. Cell. Biol. 18 (2): 676–84. PMC 108778 . PMID 9447963.
- Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A Novel Dead Box Protein That Interacts with Smn, the Spinal Muscular Atrophy Gene Product, and Is a Component of Gems". J. Cell Biol. 147 (6): 1181–94. PMC 2168095 . PMID 10601333. doi:10.1083/jcb.147.6.1181.
- Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4: A Novel Component of the Smn Complex That Is Found in Both Gems and Nucleoli". J. Cell Biol. 148 (6): 1177–86. PMC 2174312 . PMID 10725331. doi:10.1083/jcb.148.6.1177.
- Helmken C, Wetter A, Rudnik-Schöneborn S, et al. (2000). "An essential SMN interacting protein (SIP1) is not involved in the phenotypic variability of spinal muscular atrophy (SMA)". Eur. J. Hum. Genet. 8 (7): 493–9. PMID 10909848. doi:10.1038/sj.ejhg.5200479.
- Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. PMID 10942426. doi:10.1093/hmg/9.13.1977.
- Young PJ, Man NT, Lorson CL, et al. (2001). "The exon 2b region of the spinal muscular atrophy protein, SMN, is involved in self-association and SIP1 binding". Hum. Mol. Genet. 9 (19): 2869–77. PMID 11092763. doi:10.1093/hmg/9.19.2869.
- Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins". Nat. Struct. Biol. 8 (1): 27–31. PMID 11135666. doi:10.1038/83014.
- Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A Functional Interaction between the Survival Motor Neuron Complex and RNA Polymerase II". J. Cell Biol. 152 (1): 75–85. PMC 2193649 . PMID 11149922. doi:10.1083/jcb.152.1.75.
- Jablonka S, Bandilla M, Wiese S, et al. (2001). "Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy". Hum. Mol. Genet. 10 (5): 497–505. PMID 11181573. doi:10.1093/hmg/10.5.497.
- Friesen WJ, Massenet S, Paushkin S, et al. (2001). "SMN, the product of the spinal muscular atrophy gene, binds preferentially to dimethylarginine-containing protein targets". Mol. Cell. 7 (5): 1111–7. PMID 11389857. doi:10.1016/S1097-2765(01)00244-1.
- Park JW, Voss PG, Grabski S, et al. (2001). "Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein". Nucleic Acids Res. 29 (17): 3595–602. PMC 55878 . PMID 11522829. doi:10.1093/nar/29.17.3595.
- Friesen WJ, Paushkin S, Wyce A, et al. (2001). "The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins". Mol. Cell. Biol. 21 (24): 8289–300. PMC 99994 . PMID 11713266. doi:10.1128/MCB.21.24.8289-8300.2001.
- Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. PMID 11714716. doi:10.1074/jbc.M109448200.
- Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. PMID 11748230. doi:10.1074/jbc.M110141200.
- Aerbajinai W, Ishihara T, Arahata K, Tsukahara T (2002). "Increased expression level of the splicing variant of SIP1 in motor neuron diseases". Int. J. Biochem. Cell Biol. 34 (6): 699–707. PMID 11943600. doi:10.1016/S1357-2725(01)00150-9.
- Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. PMID 12065586. doi:10.1074/jbc.M203478200.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
