Sulfur dioxygenase

Sulfur dioxygenase
Identifiers
EC number 1.13.11.18
CAS number 37256-58-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Sulfur dioxygenase (EC 1.13.11.18, sulfur oxygenase, sulfur:oxygen oxidoreductase) is an enzyme with systematic name S-sulfanylglutathione:oxygen oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

sulfur + O2 + H2O sulfite + 2 H+ (overall reaction)
(1a) glutathione + sulfur S-sulfanylglutathione (spontaneous reaction)
(1b) S-sulfanylglutathione + O2 + H2O glutathione + sulfite + 2 H+

This enzyme contains iron.

In humans, sulfur dioxygenase is needed to detoxify sulfide.[3]

References

  1. Suzuki, I.; Silver, M. (1966). "The initial product and properties of the sulfur-oxidizing enzyme of thiobacilli". Biochim. Biophys. Acta. 122: 22–33. PMID 5968172. doi:10.1016/0926-6593(66)90088-9.
  2. Rohwerder, T.; Sand, W. (2003). "The sulfane sulfur of persulfides is the actual substrate of the sulfur-oxidizing enzymes from Acidithiobacillus and Acidiphilium spp". Microbiology. 149: 1699–1710. PMID 12855721. doi:10.1099/mic.0.26212-0.
  3. Viscomi, C.; Burlina, A.B.; Dweikat, I.; Savoiardo, M.; Lamperti, C.; Hildebrandt, T.; Tiranti, V.; Zeviani, M. (2010). "Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy". Nat Med. 16: 869–71. PMID 20657580. doi:10.1038/nm.2188.
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