Sulfisomidine

Sulfisomidine
Clinical data


Routes of administration	Oral
ATC code	J01EB01 (WHO)
Pharmacokinetic data
Metabolism	Minor acetylation
Excretion	Renal, 85%
Identifiers
IUPAC name 4-amino-N-(2,6-dimethylpyrimidin-4-yl) benzenesulfonamide
CAS Number	515-64-0^N
PubChem CID	5343
ChemSpider	5150^Y
UNII	W03L3ODK6E
KEGG	D01526^Y
ChEBI	CHEBI:32166^Y
ChEMBL	CHEMBL485696^Y
ECHA InfoCard	100.007.460
Chemical and physical data
Formula	C₁₂H₁₄N₄O₂S
Molar mass	278.331 g/mol
3D model (JSmol)	Interactive image
SMILES O=S(=O)(Nc1nc(nc(c1)C)C)c2ccc(N)cc2
InChI InChI=1S/C12H14N4O2S/c1-8-7-12(15-9(2)14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)^Y Key:YZMCKZRAOLZXAZ-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Sulfisomidine (INN), also known as sulphasomidine (BAN until 2003),^[1] sulfamethin and sulfaisodimidine, is a sulfonamide antibacterial. It is closely related to sulfadimidine.

References

↑ "Changing substance names from BANs to rINNs." (PDF). (34.5 KiB). United Kingdom Medicines and Healthcare products Regulatory Agency (December 12, 2003). Retrieved on 2007-08-26 through Archive.org.

External links

Melander A, Bitzén PO, Olsson S (1982). "Therapeutic equivalence of sulfaisodimidine 2 g twice daily and 1 g four times daily in lower urinary tract infections". Acta medica Scandinavica. 211 (5): 361–4. PMID 7051761. doi:10.1111/j.0954-6820.1982.tb01962.x.

Antibacterials: nucleic acid inhibitors (J01E, J01M)

Antifolates
(inhibits
purine metabolism,
thereby inhibiting
DNA and RNA synthesis)

DHFR inhibitor

2,4-Diaminopyrimidine
- Trimethoprim^#
- Brodimoprim
- Tetroxoprim
- Iclaprim^†

Sulfonamides
(DHPS inhibitor)

Short- acting	Sulfaisodimidine Sulfamethizole Sulfadimidine Sulfapyridine Sulfafurazole Sulfanilamide Prontosil Sulfathiazole Sulfathiourea
Intermediate- acting	Sulfamethoxazole Sulfadiazine^# Sulfamoxole
Long- acting	Sulfadimethoxine Sulfadoxine Sulfalene Sulfametomidine Sulfametoxydiazine Sulfamethoxypyridazine Sulfaperin Sulfamerazine Sulfaphenazole Sulfamazone
Other/ungrouped	Sulfacetamide Sulfadicramide Sulfametrole Sulfanitran

Combinations

Other DHPS inhibitors

Dapsone

Topoisomerase
inhibitors/
quinolones/
(inhibits
DNA replication)

1st g.

Fluoro-
quinolones

2nd g.	Ciprofloxacin^# Ofloxacin Enoxacin^‡ Fleroxacin^‡ Lomefloxacin^‡ Nadifloxacin^‡ Norfloxacin^‡ Pefloxacin^‡ Rufloxacin^‡
3rd g.	Levofloxacin^# Balofloxacin^‡ Grepafloxacin^‡ Pazufloxacin^‡ Sparfloxacin^‡ Temafloxacin^‡ Tosufloxacin^‡
4th g.	Besifloxacin Gatifloxacin Finafloxacin Gemifloxacin Moxifloxacin Clinafloxacin^† Garenoxacin^‡ Prulifloxacin^‡ Sitafloxacin^‡ Trovafloxacin^‡/Alatrofloxacin^‡
Vet.	Danofloxacin Difloxacin Enrofloxacin Ibafloxacin Marbofloxacin Orbifloxacin Pradofloxacin Sarafloxacin

Newer non-fluorinated

Nemonoxacin

Related (DG)

Aminocoumarins: Novobiocin

Anaerobic DNA
inhibitors

Nitro- imidazole derivatives	Metronidazole^# Tinidazole Ornidazole
Nitrofuran derivatives	Nitrofurantoin^# Furazolidone^‡ Nifurtoinol

RNA synthesis

Rifamycins/ RNA polymerase	Rifampicin^# Rifabutin^# Rifapentine^# Rifaximin Rifalazil^§

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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