Stromal vascular fraction
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Stromal Vascular Fraction |
Stromal vascular fraction (SVF) of adipose tissue is a rich source of preadipocytes, mesenchymal stem cells (MSC), endothelial progenitor cell, T cells, B cells, mast cells as well as adipose tissue macrophages.[1][2]
Introduction
Stromal Vascular Fraction (SVF) is a component of the lipoaspirate obtained from liposuction of excess adipose tissue. Lipoaspirate, the waste product of liposuction (cosmetic surgery), contains a large population of stem cells called adipose derived stem cells (ADSCs), which share a number of similarities with bone marrow stem cells, including the capacity for multilineage differentiation. Autologous SVFs containing ADSCs are currently being used in clinical settings for various orthopedic applications for human patients without any serious side effects.[3] [4]
References
- ↑ Riordan, NH; Ichim, TE; Min, WP; Wang, H; Solano, F; Lara, F; Alfaro, M; Rodriguez, JP; Harman, RJ; Patel, AN; Murphy, MP; Lee, RR; Minev, B (Apr 24, 2009). "Non-expanded adipose stromal vascular fraction cell therapy for multiple sclerosis.". Journal of translational medicine. 7: 29. PMC 2679713
. PMID 19393041. doi:10.1186/1479-5876-7-29. - ↑ Schipper HS, Prakken B, Kalkhoven E, Boes M. Adipose tissue-resident immune cells: key players in immunometabolism. Trends Endocrinol Metab 2012; 23:407-15.
- ↑ Pak, J.; Lee, J. H.; Park, K. S.; Park, M.; Kang, L.-W.; Lee, S. H. (2017). "Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications". J. Biomed. Sci. 24: 9. PMC 5282826 . PMID 28143470. doi:10.1186/s12929-017-0318-z.
- ↑ Pak, J.; Lee, J. H.; Park, K. S.; Jeon, J. H.; Lee, S. H. (2017). "Potential use of mesenchymal stem cells in human meniscal repair: current insights". Open Access J. Sports Med. 8: 33–38. PMC 5367609 . PMID 28356779. doi:10.2147/OAJSM.S113018.