Streptolydigin

Streptolydigin
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
ChEBI
ChEMBL
Chemical and physical data
Formula C32H44N2O9
Molar mass 600.708 g/mol
3D model (JSmol)
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Streptolydigin (Stl) is an antibiotic that works by inhibiting nucleic acid chain elongation by binding to RNA polymerase, thus inhibiting RNA synthesis inside a cell.[1][2][3] Streptolydigin inhibits bacterial RNA polymerase, but not eukaryotic RNA polymerase.[4] It has antibacterial activity against a number of Gram positive bacteria.

References

  1. ↑ Tuske, S.; Sarafianos, S.; Wang, X.; Hudson, B.; Sineva, E.; Mukhopadhyay, J.; Birktoft, J.; Leroy, O.; Ismail, S.; Clark, A.; Dharia, C.; Napoli, A.; Laptenko, O.; Lee, J.; Borokhov, S.; Arnold, E.; Ebright, R. (2005). "Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation". Cell. 122 (4): 541–552. PMC 2754413 Freely accessible. PMID 16122422. doi:10.1016/j.cell.2005.07.017.
  2. ↑ Temiakov, D; Zenkin, N; Vassylyeva, M. N.; Perederina, A; Tahirov, T. H.; Kashkina, E; Savkina, M; Zorov, S; Nikiforov, V; Igarashi, N; Matsugaki, N; Wakatsuki, S; Severinov, K; Vassylyev, D. G. (2005). "Structural basis of transcription inhibition by antibiotic streptolydigin". Molecular Cell. 19 (5): 655–66. PMID 16167380. doi:10.1016/j.molcel.2005.07.020.
  3. ↑ Vassylyev, D. G.; Vassylyeva, M. N.; Zhang, J; Palangat, M; Artsimovitch, I; Landick, R (2007). "Structural basis for substrate loading in bacterial RNA polymerase". Nature. 448 (7150): 163–8. PMID 17581591. doi:10.1038/nature05931.
  4. ↑ Tuske, S.; Sarafianos, S.; Wang, X.; Hudson, B.; Sineva, E.; Mukhopadhyay, J.; Birktoft, J.; Leroy, O.; Ismail, S.; Clark, A.; Dharia, C.; Napoli, A.; Laptenko, O.; Lee, J.; Borokhov, S.; Arnold, E.; Ebright, R. (2005). "Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation". Cell. 122 (4): 541–552. PMC 2754413 Freely accessible. PMID 16122422. doi:10.1016/j.cell.2005.07.017.


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