Src family kinase

Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck, Blk, and Lyn in the SrcB subfamily, and Frk in its own subfamily. Frk has homologs in invertebrates such as flies and worms, and Src homologs exist in organisms as diverse as unicellular choanoflagellates, but the SrcA and SrcB subfamilies are specific to vertebrates. Src family kinases contain six conserved domains: a N-terminal myristoylated segment, a SH2 domain, a SH3 domain, a linker region, a tyrosine kinase domain, and C-terminal tail. [1]

Src family kinases interact with many cellular cytosolic, nuclear and membrane proteins, modifying these proteins by phosphorylation of tyrosine residues. A number of substrates have been discovered for these enzymes.[2][3][4] Deregulation, including constitutive activation or over expression, may contribute to the progression of cellular transformation and oncogenic activity.[5]

References

  1. ↑ Parsons SJ, Parsons JT (October 2004). "Src family kinases, key regulators of signal transduction". Oncogene. 23 (48): 7906–9. PMID 15489908. doi:10.1038/sj.onc.1208160.
  2. ↑ Amanchy R, Zhong J, Hong R, Kim JH, Gucek M, Cole RN, Molina H, Pandey A (December 2009). "Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling". Molecular Oncology. 3 (5-6): 439–50. PMID 19632164. doi:10.1016/j.molonc.2009.07.001.
  3. ↑ Amanchy R, Zhong J, Molina H, Chaerkady R, Iwahori A, Kalume DE, Grønborg M, Joore J, Cope L, Pandey A (September 2008). "Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays". Journal of Proteome Research. 7 (9): 3900–10. PMID 18698806. doi:10.1021/pr800198w.
  4. ↑ Luo W, Slebos RJ, Hill S, Li M, Brábek J, Amanchy R, Chaerkady R, Pandey A, Ham AJ, Hanks SK (August 2008). "Global impact of oncogenic Src on a phosphotyrosine proteome". Journal of Proteome Research. 7 (8): 3447–60. PMID 18563927. doi:10.1021/pr800187n.
  5. ↑ Zhang S, Yu D (March 2012). "Targeting Src family kinases in anti-cancer therapies: turning promise into triumph". Trends in Pharmacological Sciences. 33 (3): 122–8. PMC 3675659 Freely accessible. PMID 22153719. doi:10.1016/j.tips.2011.11.002.

See also

Proto-oncogene_tyrosine-protein_kinase_Src

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