R-4066

R-4066

Identifiers
IUPAC name 6-{3,4-dihydro-2H-spiro[naphthalene-1,4'-piperidine]-1'-yl}-4,4-diphenylhexan-3-one
Synonyms	N-(3,3-diphenyl-4-oxohex-1-yl)-7,8-benzo-3-azaspiro[5.5]undecane
CAS Number	Oxalate: 101564-56-1 N
PubChem CID	380029
ChemSpider	336763 N
ChEMBL	CHEMBL2010535 N
Chemical and physical data
Formula	C32H37NO
Molar mass	451.65 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(=O)C(CCN1CCC2(CCCC3=CC=CC=C32)CC1)(C4=CC=CC=C4)C5=CC=CC=C5
InChI InChI=1S/C32H37NO/c1-2-30(34)32(27-14-5-3-6-15-27,28-16-7-4-8-17-28)22-25-33-23-20-31(21-24-33)19-11-13-26-12-9-10-18-29(26)31/h3-10,12,14-18H,2,11,13,19-25H2,1H3 N Key:ZVFXEHSJPKPKDW-UHFFFAOYSA-N N
NY (what is this?)  (verify)

R-4066 (Spirodone) is a drug which is an analogue of the opioid analgesic methadone, or more accurately norpipanone, where the metabolically labile dimethylamino group has been replaced by a piperidinospiro group. Developed by Janssen Pharmaceutica,^[1] it is around 212x more potent than methadone as an analgesic in animal tests, with an effective oral dosage of 0.07 mg/kg, but is shorter acting, with a duration of action of around 3 hours. If the ketone function is reduced and acetylated, the racemate 106 x methadone and has an analgesic duration of 20.5 hours compared to 8 hours for methadone.^[2]

R-4066 has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal.

See also

• L-687,384

References