SGPL1

SGPL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSGPL1, S1PL, SPL, sphingosine-1-phosphate lyase 1
External IDsMGI: 1261415 HomoloGene: 2897 GeneCards: SGPL1
Gene location (Human)
Chr.Chromosome 10 (human)[1]
BandNo data availableStart70,815,961 bp[1]
End70,881,173 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8879

20397

Ensembl

ENSG00000166224

ENSMUSG00000020097

UniProt

O95470

Q8R0X7

RefSeq (mRNA)

NM_003901

NM_009163
NM_001316673
NM_001316674

RefSeq (protein)

NP_003892

NP_001303602
NP_001303603
NP_033189

Location (UCSC)Chr 10: 70.82 – 70.88 MbChr 10: 61.1 – 61.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sphingosine-1-phosphate lyase 1 is an enzyme that in humans is encoded by the SGPL1 gene.[5][6][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166224 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020097 - Ensembl, May 2017
  3. "Human PubMed Reference:".
  4. "Mouse PubMed Reference:".
  5. Zhou J, Saba JD (Mar 1998). "Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast". Biochem Biophys Res Commun. 242 (3): 502–7. PMID 9464245. doi:10.1006/bbrc.1997.7993.
  6. Oskouian B, Sooriyakumaran P, Borowsky AD, Crans A, Dillard-Telm L, Tam YY, Bandhuvula P, Saba JD (Nov 2006). "Sphingosine-1-phosphate lyase potentiates apoptosis via p53- and p38-dependent pathways and is down-regulated in colon cancer". Proc Natl Acad Sci U S A. 103 (46): 17384–9. PMC 1859938Freely accessible. PMID 17090686. doi:10.1073/pnas.0600050103.
  7. "Entrez Gene: SGPL1 sphingosine-1-phosphate lyase 1".

Further reading


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