Sperm-associated antigen 5

SPAG5

Identifiers

SPAG5, DEEPEST, MAP126, hMAP126, Sperm associated antigen 5

External IDs

MGI: 1927470 HomoloGene: 4718 GeneCards: SPAG5

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	28,577,565 bp^[1]
Band	No data available	End	28,599,279 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	78,301,529 bp^[2]
Band	No data available	End	78,322,457 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • microtubule binding
Cellular component	• spindle • mitotic spindle • chromosome • microtubule organizing center • centriolar satellite • condensed chromosome kinetochore • spindle pole • chromosome, centromeric region • microtubule plus-end • midbody • microtubule • kinetochore • cytoskeleton • spindle microtubule • cytoplasm • mitotic spindle pole
Biological process	• mitotic sister chromatid segregation • cell cycle • spindle organization • cell division • protein localization to centrosome • chromosome segregation • regulation of attachment of spindle microtubules to kinetochore • establishment of spindle orientation • positive regulation of intracellular transport • regulation of metaphase plate congression • positive regulation of spindle assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10615


54141

Ensembl


ENSG00000076382


ENSMUSG00000002055

UniProt


Q96R06


Q7TME2

RefSeq (mRNA)


NM_006461


NM_017407

RefSeq (protein)


NP_006452


NP_059103

Location (UCSC)

Chr 17: 28.58 – 28.6 Mb

Chr 17: 78.3 – 78.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene.^[5]^[6]

This gene encodes a protein associated with the mitotic spindle apparatus. The encoded protein may be involved in the functional and dynamic regulation of mitotic spindles.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000076382 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002055 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Chang MS, Huang CJ, Chen ML, Chen ST, Fan CC, Chu JM, Lin WC, Yang YC (Sep 2001). "Cloning and characterization of hMAP126, a new member of mitotic spindle-associated proteins". Biochem Biophys Res Commun. 287 (1): 116–21. PMID 11549262. doi:10.1006/bbrc.2001.5554.
1 2 "Entrez Gene: SPAG5 sperm associated antigen 5".

Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. PMID 10531379. doi:10.1074/jbc.274.44.31693.
Shao X, Xue J, van der Hoorn FA (2001). "Testicular protein Spag5 has similarity to mitotic spindle protein Deepest and binds outer dense fiber protein Odf1". Mol. Reprod. Dev. 59 (4): 410–6. PMID 11468777. doi:10.1002/mrd.1047.
Mack GJ, Compton DA (2002). "Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein". Proc. Natl. Acad. Sci. U.S.A. 98 (25): 14434–9. PMC 64699 . PMID 11724960. doi:10.1073/pnas.261371298.
Gruber J, Harborth J, Schnabel J, et al. (2003). "The mitotic-spindle-associated protein astrin is essential for progression through mitosis". J. Cell. Sci. 115 (Pt 21): 4053–9. PMID 12356910. doi:10.1242/jcs.00088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. PMID 15504738. doi:10.1074/jbc.M403080200.
Yang YC, Hsu YT, Wu CC, et al. (2006). "Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells". Biochem. Biophys. Res. Commun. 343 (2): 428–34. PMID 16546135. doi:10.1016/j.bbrc.2006.02.166.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. PMC 1459365 . PMID 16565220. doi:10.1073/pnas.0507066103.
Cheng TS, Hsiao YL, Lin CC, et al. (2007). "hNinein is required for targeting spindle-associated protein Astrin to the centrosome during the S and G2 phases". Exp. Cell Res. 313 (8): 1710–21. PMID 17383637. doi:10.1016/j.yexcr.2007.02.023.

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Sperm-associated antigen 5

References

Further reading