Solute carrier family

The solute carrier (SLC) group of membrane transport proteins include over 400 members organized into 52 families.^[1]^[2]^[3] Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the basis for the official HGNC names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.

Solutes that are transported by the various SLC group members are extraordinarily diverse and include both charged and uncharged organic molecules as well as inorganic ions and the gas ammonia.

As is typical of integral membrane proteins, SLCs contain a number of hydrophobic transmembrane alpha helices connected to each other by hydrophilic intra- and extra-cellular loops. Depending on the SLC, these transporters are functional as either monomers or obligate homo- or hetero-oligomers.

Scope

By convention of the nomenclature system, members within an individual SLC family have greater than 20-25% sequence homology to each other. In contrast, the homology between SLC families is very low to non-existent.^[4] Hence, the criteria for inclusion of a family into the SLC group is not evolutionary relatedness to other SLC families but rather functional (i.e., an integral membrane protein that transports a solute).

The SLC group include examples of transport proteins that are:

facilitative transporters (allow solutes to flow downhill with their electrochemical gradients)
secondary active transporters (allow solutes to flow uphill against their electrochemical gradient by coupling to transport of a second solute that flows downhill with its gradient such that the overall free energy change is still favorable)

The SLC series does not include members of transport protein families that have previously been classified by other widely accepted nomenclature systems including:

primary active transporters (allow flow uphill against electrochemical gradients) such as ABC (ATP Binding Cassette) transporters by coupling transport to an energy releasing event such as ATP hydrolysis
ion channels
aquaporins (water channels)

Subcellular distribution

Most members of the SLC group are located in the cell membrane, but some members are located in mitochondria (the most notable one being SLC family 25) or other intracellular organelles.

Nomenclature system

Names of individual SLC members have the following format:

SLCnXm

where:

SLC is the root name (SoLute Carrier)
n = an integer representing a family (e.g., 1-47)
X = a single letter (A, B, C, ...) denoting a subfamily
m = an integer representing an individual family member (isoform).

For example, SLC1A1 is the first isoform of subfamily A of SLC family 1.

An exception occurs with SLC family 21 (the organic anion transporting polypeptide transporters), which for historical reasons have names in the format SLCOnXm where n = family number, X = subfamily letter, and m = member number.

While the HGNC nomenclature system by definition only includes human genes, the nomenclature system has been informally extended to include rodent species through the use of lowercase letters (e.g., Slc1a1 denotes the rodent ortholog of the human SLC1A1 gene).

Families

(1) high-affinity glutamate and neutral amino acid transporter^[5]
- (SLC1A1, SLC1A2, SLC1A3, SLC1A4, SLC1A5, SLC1A6, SLC1A7)
(2) facilitative GLUT transporter^[6]
- (SLC2A1, SLC2A2, SLC2A3, SLC2A4, SLC2A5, SLC2A6, SLC2A7, SLC2A8, SLC2A9, SLC2A10, SLC2A11, SLC2A12, SLC2A13, SLC2A14)
(3) heavy subunits of heterodimeric amino acid transporters^[7]
- (SLC3A1, SLC3A2)
(4) bicarbonate transporter^[8]
- (SLC4A1, SLC4A2, SLC4A3, SLC4A4, SLC4A5, SLC4A6, SLC4A7, SLC4A8, SLC4A9, SLC4A10, SLC4A11)
(5) sodium glucose cotransporter^[9]
- (SLC5A1, SLC5A2, SLC5A3, SLC5A4, SLC5A5, SLC5A6, SLC5A7, SLC5A8, SLC5A9, SLC5A10, SLC5A11, SLC5A12)
(6) sodium- and chloride-dependent sodium:neurotransmitter symporters^[10]
- (SLC6A1, SLC6A2, SLC6A3, SLC6A4, SLC6A5, SLC6A6, SLC6A7, SLC6A8, SLC6A9, SLC6A10, SLC6A11, SLC6A12, SLC6A13, SLC6A14, SLC6A15, SLC6A16, SLC6A17, SLC6A18, SLC6A19, SLC6A20)
(7) cationic amino acid transporter/glycoprotein-associated^[11]
- cationic amino acid transporters (SLC7A1, SLC7A2, SLC7A3, SLC7A4)
- glycoprotein-associated/light or catalytic subunits of heterodimeric amino acid transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A9, SLC7A10, SLC7A11, SLC7A13, SLC7A14)
(8) Na+/Ca2+ exchanger^[12]
- (SLC8A1, SLC8A2, SLC8A3)
(9) Na+/H+ exchanger^[13]
- (SLC9A1, SLC9A2, SLC9A3, SLC9A4, SLC9A5, SLC9A6, SLC9A7, SLC9A8, SLC9A9, SLC9A10, SLC9A11, SLC9B1, SLC9B2)
(10) sodium bile salt cotransport^[14]
- (SLC10A1, SLC10A2, SLC10A3, SLC10A4, SLC10A5, SLC10A6, SLC10A7)
(11) proton coupled metal ion transporter^[15]
- (SLC11A1, SLC11A2)
(12) electroneutral cation-Cl cotransporter^[16]
- (SLC12A1, SLC12A1, SLC12A2, SLC12A3, SLC12A4, SLC12A5, SLC12A6, SLC12A7, SLC12A8, SLC12A9)
(13) Na+-sulfate/carboxylate cotransporter^[17]
- (SLC13A1, SLC13A2, SLC13A3, SLC13A4, SLC13A5)
(14) urea transporter^[18]
- (SLC14A1, SLC14A2)
(15) proton oligopeptide cotransporter^[19]
- (SLC15A1, SLC15A2, SLC15A3, SLC15A4)
(16) monocarboxylate transporter^[20]
- (SLC16A1, SLC16A2, SLC16A3, SLC16A4, SLC16A5, SLC16A6, SLC16A7, SLC16A8, SLC16A9, SLC16A10, SLC16A11, SLC16A12, SLC16A13, SLC16A14)
(17) vesicular glutamate transporter^[21]
- (SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC17A5, SLC17A6, SLC17A7, SLC17A8, SLC17A9)
(18) vesicular amine transporter^[22]
- (SLC18A1, SLC18A2, SLC18A3)
(19) folate/thiamine transporter^[23]
- (SLC19A1, SLC19A2, SLC19A3)
(20) type III Na+-phosphate cotransporter^[24]
- (SLC20A1, SLC20A2)
(21) organic anion transporting^[25]
- subfamily 1 (SLCO1A2, SLCO1B1, SLCO1B3, SLCO1C1)
- subfamily 2 (SLCO2A1, SLCO2B1)
- subfamily 3 (SLCO3A1)
- subfamily 4 (SLCO4A1, SLCO4C1)
- subfamily 5 (SLCO5A1)
- subfamily 6 (SLCO6A1)
(22) organic cation/anion/zwitterion transporter^[26]
- (SLC22A1, SLC22A2, SLC22A3, SLC22A4, SLC22A5, SLC22A6, SLC22A7, SLC22A8, SLC22A9, SLC22A10, SLC22A11, SLC22A12, SLC22A13, SLC22A14, SLC22A15, SLC22A16, SLC22A17, SLC22A18, SLC22A18AS, SLC22A19, SLC22A20, SLC22A23, SLC22A24, SLC22A25, SLC22A31)
(23) Na+-dependent ascorbic acid transporter^[27]
- (SLC23A1, SLC23A2, SLC23A3, SLC23A4)
(24) Na+/(Ca2+-K+) exchanger^[28]
- (SLC24A1, SLC24A2, SLC24A3, SLC24A4, SLC24A5, SLC24A6)
(25) mitochondrial carrier^[29]
- (SLC25A1, SLC25A2, SLC25A3, SLC25A4, SLC25A5, SLC25A6, SLC25A7, SLC25A8, SLC25A9, SLC25A10, SLC25A11, SLC25A12, SLC25A13, SLC25A14, SLC25A15, SLC25A16, SLC25A17, SLC25A18, SLC25A19, SLC25A20, SLC25A21, SLC25A22, SLC25A23, SLC25A24, SLC25A25, SLC25A26, SLC25A27, SLC25A28, SLC25A29, SLC25A30, SLC25A31, SLC25A32, SLC25A33, SLC25A34, SLC25A35, SLC25A36, SLC25A37, SLC25A38, SLC25A39, SLC25A40, SLC25A41, SLC25A42, SLC25A43, SLC25A44, SLC25A45, SLC25A46)
(26) multifunctional anion exchanger^[30]
- (SLC26A1, SLC26A2, SLC26A3, SLC26A4, SLC26A5, SLC26A6, SLC26A7, SLC26A8, SLC26A9, SLC26A10, SLC26A11)
(27) fatty acid transport proteins^[31]
- (SLC27A1, SLC27A2, SLC27A3, SLC27A4, SLC27A5, SLC27A6)
(28) Na+-coupled nucleoside transport^[32]
- (SLC28A1, SLC28A2, SLC28A3)
(29) facilitative nucleoside transporter^[33]
- (SLC29A1, SLC29A2, SLC29A3, SLC29A4)
(30) zinc transporter^[34]
- (SLC30A1, SLC30A2, SLC30A3, SLC30A4, SLC30A5, SLC30A6, SLC30A7, SLC30A8, SLC30A9, SLC30A10)
(31) copper transporter^[35]
- (SLC31A1, SLC31A2)
(32) vesicular inhibitory amino acid transporter^[36]
- (SLC32A1)
(33) Acetyl-CoA transporter^[37]
- (SLC33A1)
(34) type II Na+-phosphate cotransporter^[38]
- (SLC34A1, SLC34A2, SLC34A3)
(35) nucleoside-sugar transporter^[39]
- subfamily A (SLC35A1, SLC35A2, SLC35A3, SLC35A4, SLC35A5)
- subfamily B (SLC35B1, SLC35B2, SLC35B3, SLC35B4)
- subfamily C (SLC35C1, SLC35C2)
- subfamily D (SLC35D1, SLC35D2, SLC35D3)
- subfamily E (SLC35E1, SLC35E2, SLC35E3, SLC35E4)
- subfamily F (SLC35F1, SLC35F2, SLC35F3, SLC35F4, SLC35F5)
- subfamily G (SLC35G1, SLC35G3, SLC35G4, SLC35G5, SLC35G6)
(36) proton-coupled amino acid transporter^[40]
- (SLC36A1, SLC36A2, SLC36A3, SLC36A4)
(37) sugar-phosphate/phosphate exchanger^[41]
- (SLC37A1, SLC37A2, SLC37A3, SLC37A4)
(38) System A & N, sodium-coupled neutral amino acid transporter^[42]
- (SLC38A1, SLC38A2, SLC38A3, SLC38A4, SLC38A5, SLC38A6, SLC38A7, SLC38A8, SLC38A9, SLC38A10, SLC38A11)
(39) metal ion transporter^[43]
- (SLC39A1, SLC39A2, SLC39A3, SLC39A4, SLC39A5, SLC39A6, SLC39A7, SLC39A8, SLC39A9, SLC39A10, SLC39A11, SLC39A12, SLC39A13, SLC39A14)
(40) basolateral iron transporter^[44]
- (SLC40A1)
(41) MgtE-like magnesium transporter
- (SLC41A1, SLC41A2, SLC41A3)
(42) Ammonia transporter^[45]^[46]
- (RhAG, RhBG, RhCG)
(43) Na+-independent, system-L like amino acid transporter
- (SLC43A1, SLC43A2, SLC43A3)
(44) Choline-like transporter
- (SLC44A1, SLC44A2, SLC44A3, SLC44A4, SLC44A5)
(45) Putative sugar transporter
- (SLC45A1, SLC45A2, SLC45A3, SLC45A4)
(46) Folate transporter
- (SLC46A1, SLC46A2, SLC46A3)
(47) multidrug and toxin extrusion
- (SLC47A1, SLC47A2)
(48) Heme transporter
(49) Transporters of the major facilitator superfamily
(50) Sugar efflux transporters of the SWEET family
(51) Transporters of steroid-derived molecules
(52) Riboflavin transporter family RFVT/SLC52

Atypical SLCs

Atypical SLCs are novel, plausible secondary active or facilitative transansporter proteins that share ancestral background with the known SLCs. However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families ^[47]

Here are some Atypical SLC listed: OCA2, CLN3, TMEM104, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1, MFSD2A, MFSD2B, MFSD3, MFSD4A, MFSD4B, MFSD5, MFSD6, MFSD6L, MFSD8, MFSD9, MFSD10, MFSD11, MFSD12, MFSD13A, MFSD14A, MFSD14B, UNC93A and UNC93B1

References

↑ Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA (2004). "The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction". Pflugers Arch. 447 (5): 465–8. PMID 14624363. doi:10.1007/s00424-003-1192-y.
↑ Perland, Emelie; Fredriksson, Robert (2016-12-08). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38: 305–315. ISSN 1873-3735. PMID 27939446. doi:10.1016/j.tips.2016.11.008.
↑ Perland, Emelie; Fredriksson, Robert (2017-03-01). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. ISSN 1873-3735. PMID 27939446. doi:10.1016/j.tips.2016.11.008.
↑ Hoglund, P. J.; Nordstrom, K. J. V.; Schioth, H. B.; Fredriksson, R. (2010). "The Solute Carrier Families Have a Remarkably Long Evolutionary History with the Majority of the Human Families Present before Divergence of Bilaterian Species". Molecular Biology and Evolution. 28 (4): 1531–1541. PMC 3058773 . PMID 21186191. doi:10.1093/molbev/msq350.
↑ Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflugers Arch. 447 (5): 469–479. PMID 14530974. doi:10.1007/s00424-003-1146-4.
↑ Uldry M, Thorens B (2004). "The SLC2 family of facilitated hexose and polyol transporters". Pflugers Arch. 447 (5): 480–489. PMID 12750891. doi:10.1007/s00424-003-1085-0.
↑ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch. 447 (5): 490–494. PMID 14770309. doi:10.1007/s00424-003-1062-7.
↑ Romero MF, Fulton CM, Boron WF (2004). "The SLC4 family of HCO 3 - transporters". Pflugers Arch. 447 (5): 490–494. PMID 14722772. doi:10.1007/s00424-003-1180-2.
↑ Wright EM, Turk E (2004). "The sodium/glucose cotransport family SLC5". Pflugers Arch. 447 (5): 510–518. PMID 12748858. doi:10.1007/s00424-003-1063-6.
↑ Chen NH, Reith ME, Quick MW (2004). "Synaptic uptake and beyond: the sodium- and chloride-dependent neurotransmitter transporter family SLC6". Pflugers Arch. 447 (5): 519–531. PMID 12719981. doi:10.1007/s00424-003-1064-5.
↑ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch. 447 (5): 532–542. PMID 14770310. doi:10.1007/s00424-003-1086-z.
↑ Quednau BD, Nicoll DA, Philipson KD (2004). "The sodium/calcium exchanger family-SLC8". Pflugers Arch. 447 (5): 543–548. PMID 12734757. doi:10.1007/s00424-003-1065-4.
↑ Orlowski J, Grinstein S (2004). "Diversity of the mammalian sodium/proton exchanger SLC9 gene family". Pflugers Arch. 447 (5): 549–565. PMID 12845533. doi:10.1007/s00424-003-1110-3.
↑ Hagenbuch B, Dawson P (2004). "The sodium bile salt cotransport family SLC10". Pflugers Arch. 447 (5): 566–570. PMID 12851823. doi:10.1007/s00424-003-1130-z.
↑ Mackenzie B, Hediger MA (2004). "SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1". Pflugers Arch. 447 (5): 571–579. PMID 14530973. doi:10.1007/s00424-003-1141-9.
↑ Hebert SC, Mount DB, Gamba G (2004). "Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family". Pflugers Arch. 447 (5): 580–593. PMID 12739168. doi:10.1007/s00424-003-1066-3.
↑ Markovich D, Murer H (2004). "The SLC13 gene family of sodium sulphate/carboxylate cotransporters". Pflugers Arch. 447 (5): 594–602. PMID 12915942. doi:10.1007/s00424-003-1128-6.
↑ Shayakul C, Hediger MA (2004). "The SLC14 gene family of urea transporters". Pflugers Arch. 447 (5): 603–609. PMID 12856182. doi:10.1007/s00424-003-1124-x.
↑ Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflugers Arch. 447 (5): 610–618. PMID 12905028. doi:10.1007/s00424-003-1101-4.
↑ Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflugers Arch. 447 (5): 619–628. PMID 12739169. doi:10.1007/s00424-003-1067-2.
↑ Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflugers Arch. 447 (5): 629–635. PMID 12811560. doi:10.1007/s00424-003-1087-y.
↑ Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflugers Arch. 447 (5): 636–640. PMID 12827358. doi:10.1007/s00424-003-1100-5.
↑ Ganapathy V, Smith SB, Prasad PD (2004). "SLC19: the folate/thiamine transporter family". Pflugers Arch. 447 (5): 641–646. PMID 14770311. doi:10.1007/s00424-003-1068-1.
↑ Collins JF, Bai L, Ghishan FK (2004). "The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors". Pflugers Arch. 447 (5): 641–646. PMID 12759754. doi:10.1007/s00424-003-1088-x.
↑ Hagenbuch B, Meier PJ (2004). "Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties". Pflugers Arch. 447 (5): 653–665. PMID 14579113. doi:10.1007/s00424-003-1168-y.
↑ Koepsell H, Endou H (2004). "The SLC22 drug transporter family". Pflugers Arch. 447 (5): 666–676. PMID 12883891. doi:10.1007/s00424-003-1089-9.
↑ Takanaga H, Mackenzie B, Hediger MA (2004). "Sodium-dependent ascorbic acid transporter family SLC23". Pflugers Arch. 447 (5): 677–682. PMID 12845532. doi:10.1007/s00424-003-1104-1.
↑ Schnetkamp PP (2004). "The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond". Pflugers Arch. 447 (5): 683–688. PMID 14770312. doi:10.1007/s00424-003-1069-0.
↑ Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflugers Arch. 447 (5): 689–709. PMID 14598172. doi:10.1007/s00424-003-1099-7.
↑ Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflugers Arch. 447 (5): 710–721. PMID 12759755. doi:10.1007/s00424-003-1090-3.
↑ Stahl A (2004). "A current review of fatty acid transport proteins (SLC27)". Pflugers Arch. 447 (5): 722–727. PMID 12856180. doi:10.1007/s00424-003-1106-z.
↑ Gray JH, Owen RP, Giacomini KM (2004). "The concentrative nucleoside transporter family, SLC28". Pflugers Arch. 447 (5): 728–734. PMID 12856181. doi:10.1007/s00424-003-1107-y.
↑ Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (2004). "The equilibrative nucleoside transporter family, SLC29". Pflugers Arch. 447 (5): 735–743. PMID 12838422. doi:10.1007/s00424-003-1103-2.
↑ Palmiter RD, Huang L (2004). "Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers". Pflugers Arch. 447 (5): 744–751. PMID 12748859. doi:10.1007/s00424-003-1070-7.
↑ Petris MJ (2004). "The SLC31 (Ctr) copper transporter family". Pflugers Arch. 447 (5): 752–755. PMID 12827356. doi:10.1007/s00424-003-1092-1.
↑ Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflugers Arch. 447 (5): 752–755. PMID 12750892. doi:10.1007/s00424-003-1091-2.
↑ Hirabayashi Y, Kanamori A, Nomura KH, Nomura K (2004). "The acetyl-CoA transporter family SLC33". Pflugers Arch. 447 (5): 760–762. PMID 12739170. doi:10.1007/s00424-003-1071-6.
↑ Murer H, Forster I, Biber J (2004). "The sodium phosphate cotransporter family SLC34". Pflugers Arch. 447 (5): 763–767. PMID 12750889. doi:10.1007/s00424-003-1072-5.
↑ Ishida N, Kawakita M (2004). "Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35)". Pflugers Arch. 447 (5): 768–775. PMID 12759756. doi:10.1007/s00424-003-1093-0.
↑ Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflugers Arch. 447 (5): 776–779. PMID 12748860. doi:10.1007/s00424-003-1073-4.
↑ Bartoloni L, Antonarakis SE (2004). "The human sugar-phosphate/phosphate exchanger family SLC37". Pflugers Arch. 447 (5): 780–783. PMID 12811562. doi:10.1007/s00424-003-1105-0.
↑ Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflugers Arch. 447 (5): 784–795. PMID 12845534. doi:10.1007/s00424-003-1117-9.
↑ Eide DJ (2004). "The SLC39 family of metal ion transporters". Pflugers Arch. 447 (5): 796–800. PMID 12748861. doi:10.1007/s00424-003-1074-3.
↑ McKie AT, Barlow DJ (2004). "The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)". Pflugers Arch. 447 (5): 801–806. PMID 12836025. doi:10.1007/s00424-003-1102-3.
↑ Nakhoul NL, Hamm LL (2004). "Non-erythroid Rh glycoproteins: a putative new family of mammalian ammonium transporters". Pflugers Arch. 447 (5): 807–812. PMID 12920597. doi:10.1007/s00424-003-1142-8.
↑ Boron, W. F. (2010). "Sharpey-Schafer Lecture Gas channels". Experimental Physiology. 95 (12): 1107–1130. PMC 3003898 . PMID 20851859. doi:10.1113/expphysiol.2010.055244.
↑ Perland, Emelie; Fredriksson, Robert (2016-12-08). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38: 305–315. ISSN 1873-3735. PMID 27939446. doi:10.1016/j.tips.2016.11.008.

SLC Tables. http://slc.bioparadigms.org

External links

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

(1):	high affinity glutamate and neutral amino-acid transporter SLC1A1 2 3 4 5 6 7
(2):	facilitative GLUT transporter SLC2A1 2 3 4 5 6 7 8 9 10 11 12 13 14
(3):	heavy subunits of heterodimeric amino-acid transporters SLC3A1 2
(4):	bicarbonate transporter SLC4A1 2 3 4 5 6 7 8 9 10 11
(5):	sodium glucose cotransporter SLC5A1 2 3 4 5 6 7 8 9 10 11 12
(6):	sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A16 SLC6A17 SLC6A18 SLC6A19 SLC6A20
(7):	cationic amino-acid transporter/glycoprotein-associated SLC7A1 SLC7A2 SLC7A3 SLC7A4 glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC7A10 SLC7A11 SLC7A13 SLC7A14
(8):	Na⁺/Ca²⁺ exchanger SLC8A1 SLC8A2 SLC8A3
(9):	Na⁺/H⁺ exchanger SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A10 SLC9A11
(10):	sodium bile salt cotransport SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 10A1 10A2 10A3 10A7

SLC11–20

(11):	proton coupled metal ion transporter SLC11A1 SLC11A2 11A3
(12):	electroneutral cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9
(13):	human Na⁺-sulfate/carboxylate cotransporter SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5
(14):	urea transporter SLC14A1 SLC14A2
(15):	proton oligopeptide cotransporter SLC15A1 SLC15A2 SLC15A3 SLC15A4
(16):	monocarboxylate transporter SLC16A1 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14
(17):	Vesicular glutamate transporter 1 SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9
(18):	vesicular monoamine transporter SLC18A1 SLC18A2 SLC18A3
(19):	folate/thiamine transporter SLC19A1 SLC19A2 SLC19A3
(20):	type III Na⁺-phosphate cotransporter SLC20A1 SLC20A2

SLC21–30

(21):	Organic anion-transporting polypeptide SLCO1A2 SLCO1B1 SLCO1B3 SLCO1B4 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 SLCO5A1(SLCO6A1)
(22):	organic cation/anion/zwitterion transporter SLC22A1 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A19 SLC22A20
(23):	Na+-dependent ascorbic acid transporter SLC23A1 SLC23A2 SLC23A3 SLC23A4
(24):	Na⁺/(Ca²⁺-K⁺) exchanger SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6
(25):	mitochondrial carrier SLC25A1 SLC25A2 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SLC25A7 SLC25A8 SLC25A9 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A18 SLC25A19 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A26 SLC25A27 SLC25A28 SLC25A29 SLC25A30 SLC25A31 SLC25A32 SLC25A33 SLC25A34 SLC25A35 SLC25A36 SLC25A37 SLC25A38 SLC25A39 SLC25A40 SLC25A41 SLC25A42 SLC25A43 SLC25A44 SLC25A45 SLC25A46
(26):	multifunctional anion exchanger SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 SLC26A10 SLC26A11
(27):	fatty acid transport proteins SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6
(28):	Na⁺-coupled nucleoside transport (SLC28A1 SLC28A2 SLC28A3
(29):	facilitative nucleoside transporter SLC29A1 SLC29A2 SLC29A3 SLC29A4
(30):	zinc efflux SLC30A1 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 SLC30A10

SLC31–40

(31):	copper transporter SLC31A1
(32):	Vesicular glutamate transporter 1 SLC32A1
(33):	Acetyl-CoA transporter SLC33A1
(34):	type II Na⁺-phosphate cotransporter SLC34A1 SLC34A2 SLC34A3
(35):	nucleoside-sugar transporter SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35D3 SLC35E1 SLC35E2 SLC35E3 SLC35E4
(36):	proton-coupled amino-acid transporter SLC36A1 SLC36A2 SLC36A3 SLC36A436A2
(37):	sugar-phosphate/phosphate exchanger SLC37A1 SLC37A2 SLC37A3 SLC37A4
(38):	System A & N, sodium-coupled neutral amino-acid transporter SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A10
(39):	metal ion transporter SLC39A1 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14
(40):	basolateral iron transporter SLC40A1

SLC41–48

(41):	Magnesium transporter E SLC41A1 SLC41A2 SLC41A3
(42):	Ammonia transporter RhAG RhBG RhCG
(43):	Na⁺-independent, system-L like amino-acid transporter SLC43A1 SLC43A2 SLC43A3
(44):	Choline-like transporter SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5
(45):	Putative sugar transporter SLC45A1 SLC45A2 SLC54A3 SLC45A4
(46):	Folate transporter SLC46A1 SLC46A2
(47):	multidrug and toxin extrusion SLC47A1 SLC47A2
(48):	Heme transporter

SLCO1–4
O1A2 O1B1 O1B3 O2B1 O431 O4A1

Ion pumps

Symporter, Cotransporter	Na⁺/K⁺,Cl⁻ Na⁺/P_i3 Na⁺/Cl⁻ Na⁺/glucose Na⁺/I⁻ Cl⁻/K⁺ 4 5
Antiporter (exchanger)	Na⁺/H⁺ Na⁺/Ca²⁺ Na⁺/(Ca²⁺-K⁺) - Cl⁻/HCO− 3 (Band 3) Cl⁻-formate Cl⁻-oxalate

see also solute carrier disorders

Genetic disorder, membrane: Solute carrier disorders
1-10	SLC1A3 Episodic ataxia 6 SLC2A1 De Vivo disease SLC2A5 Fructose malabsorption SLC2A10 Arterial tortuosity syndrome SLC3A1 Cystinuria SLC4A1 Hereditary spherocytosis 4/Hereditary elliptocytosis 4 SLC4A11 Congenital endothelial dystrophy type 2 Fuchs' dystrophy 4 SLC5A1 Glucose-galactose malabsorption SLC5A2 Renal glycosuria SLC5A5 Thyroid dyshormonogenesis type 1 SLC6A19 Hartnup disease SLC7A7 Lysinuric protein intolerance SLC7A9 Cystinuria
11-20	SLC11A1 Crohn's disease SLC12A3 Gitelman syndrome SLC16A1 HHF7 SLC16A2 Allan–Herndon–Dudley syndrome SLC17A5 Salla disease SLC17A8 DFNA25
21-40	SLC26A2 Multiple epiphyseal dysplasia 4 Achondrogenesis type 1B Recessive multiple epiphyseal dysplasia Atelosteogenesis, type II Diastrophic dysplasia SLC26A4 Pendred syndrome SLC35C1 CDOG 2C SLC39A4 Acrodermatitis enteropathica SLC40A1 African iron overload
see also solute carrier family

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