Small nucleolar RNA SNORA76
| Small nucleolar RNA SNORA76 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA76 | |
| Identifiers | |
| Symbol | SNORA76 |
| Rfam | RF00598 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; HACA-box |
| Domain(s) | Eukaryota |
| GO | 0006396 0005730 |
| SO | 0000594 |
In molecular biology, SNORA76 (also known as ACA62) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.[1]
This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis.[2] ACA62 is proposed to guide the pseudouridylation of 18S rRNA U34 and U105.[2][3]
References
- ↑ Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. PMC 480876
. PMID 15199136. doi:10.1128/MCB.24.13.5797-5807.2004. - 1 2 Schattner P, Barberan-Soler S, Lowe TM; (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. PMC 1370881 . PMID 16373490. doi:10.1261/rna.2210406.
- ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552 . PMC 1347365 . PMID 16381836. doi:10.1093/nar/gkj002.
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