Small nuclear ribonucleoprotein polypeptide A

SNRPA

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
1AUD, 1DRZ, 1DZ5, 1FHT, 1M5K, 1M5O, 1M5P, 1M5V, 1NU4, 1OIA, 1SJ3, 1SJ4, 1SJF, 1U6B, 1URN, 1VBX, 1VBY, 1VBZ, 1VC0, 1VC5, 1VC6, 1ZZN, 2A3J, 2NZ4, 2OIH, 2OJ3, 2U1A, 3BO2, 3BO3, 3BO4, 3CUL, 3CUN, 3EGZ, 3G8S, 3G8T, 3G96, 3G9C, 3HHN, 3IIN, 3IRW, 3IWN, 3K0J, 3L3C, 3MUM, 3MUR, 3MUT, 3MUV, 3MXH, 3P49, 3PGW, 3R1H, 3R1L, 3UCU, 3UCZ, 3UD3, 3UD4, 4C4W, 4PR6, 4PRF, 4W90, 4YB1, 5DDO, 5DDR, 5DDQ, 5DDP, 5FJ4

Identifiers

Aliases

SNRPA, Mud1, U1-A, U1A, Small nuclear ribonucleoprotein polypeptide A

External IDs

HomoloGene: 3380 GeneCards: SNRPA

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	No data available	Start	40,750,637 bp^[1]
Band	No data available	End	40,765,389 bp^[1]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• U1 snRNA binding • snRNA stem-loop binding • protein binding • RNA binding • nucleic acid binding • U1 snRNP binding • identical protein binding
Cellular component	• spliceosomal complex • intracellular ribonucleoprotein complex • nucleus • nucleoplasm • U1 snRNP
Biological process	• mRNA processing • regulation of mRNA polyadenylation • RNA splicing • mRNA splicing, via spliceosome
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6626


n/a

Ensembl


ENSG00000077312


n/a

UniProt


P09012


n/a

RefSeq (mRNA)


NM_004596


n/a

RefSeq (protein)


NP_004587


n/a

Location (UCSC)

Chr 19: 40.75 – 40.77 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

U1 small nuclear ribonucleoprotein A is a protein that in humans is encoded by the SNRPA gene.^[3]^[4]

Interactions

Small nuclear ribonucleoprotein polypeptide A has been shown to interact with CDC5L.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000077312 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ Schonk D, van Dijk P, Riegmann P, Trapman J, Holm C, Willcocks TC, Sillekens P, van Venrooij W, Wimmer E, Geurts van Kessel A, et al. (January 1991). "Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region". Cytogenet Cell Genet. 54 (1-2): 15–9. PMID 1701111. doi:10.1159/000132946.
↑ "Entrez Gene: SNRPA small nuclear ribonucleoprotein polypeptide A".
↑ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. ISSN 0261-4189. PMC 305846 . PMID 11101529. doi:10.1093/emboj/19.23.6569.

Hoffman DW, Query CC, Golden BL, et al. (1991). "RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.". Proc. Natl. Acad. Sci. U.S.A. 88 (6): 2495–9. PMC 51259 . PMID 1826055. doi:10.1073/pnas.88.6.2495.
Nelissen RL, Sillekens PT, Beijer RP, et al. (1991). "Structure, chromosomal localization and evolutionary conservation of the gene encoding human U1 snRNP-specific A protein.". Gene. 102 (2): 189–96. PMID 1831431. doi:10.1016/0378-1119(91)90077-O.
Jessen TH, Oubridge C, Teo CH, et al. (1991). "Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.". EMBO J. 10 (11): 3447–56. PMC 453073 . PMID 1833186.
Nagai K, Oubridge C, Jessen TH, et al. (1991). "Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A.". Nature. 348 (6301): 515–20. PMID 2147232. doi:10.1038/348515a0.
Sillekens PT, Habets WJ, Beijer RP, van Venrooij WJ (1988). "cDNA cloning of the human U1 snRNA-associated A protein: extensive homology between U1 and U2 snRNP-specific proteins.". EMBO J. 6 (12): 3841–8. PMC 553857 . PMID 2962859.
Oubridge C, Ito N, Evans PR, et al. (1994). "Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.". Nature. 372 (6505): 432–8. PMID 7984237. doi:10.1038/372432a0.
Howe PW, Nagai K, Neuhaus D, Varani G (1994). "NMR studies of U1 snRNA recognition by the N-terminal RNP domain of the human U1A protein.". EMBO J. 13 (16): 3873–81. PMC 395300 . PMID 8070414.
Allain FH, Gubser CC, Howe PW, et al. (1996). "Specificity of ribonucleoprotein interaction determined by RNA folding during complex formulation.". Nature. 380 (6575): 646–50. PMID 8602269. doi:10.1038/380646a0.
Avis JM, Allain FH, Howe PW, et al. (1996). "Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.". J. Mol. Biol. 257 (2): 398–411. PMID 8609632. doi:10.1006/jmbi.1996.0171.
Lu J, Hall KB (1997). "Tertiary structure of RBD2 and backbone dynamics of RBD1 and RBD2 of the human U1A protein determined by NMR spectroscopy.". Biochemistry. 36 (34): 10393–405. PMID 9265619. doi:10.1021/bi9709811.
Allain FH, Howe PW, Neuhaus D, Varani G (1997). "Structural basis of the RNA-binding specificity of human U1A protein.". EMBO J. 16 (18): 5764–72. PMC 1170207 . PMID 9312034. doi:10.1093/emboj/16.18.5764.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. PMID 9731529. doi:10.1038/1700.
Ferré-D'Amaré AR, Zhou K, Doudna JA (1998). "Crystal structure of a hepatitis delta virus ribozyme.". Nature. 395 (6702): 567–74. PMID 9783582. doi:10.1038/26912.
Lutz CS, Cooke C, O'Connor JP, et al. (1998). "The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor.". RNA. 4 (12): 1493–9. PMC 1369720 . PMID 9848648. doi:10.1017/S1355838298981183.
Hetzer M, Mattaj IW (2000). "An ATP-dependent, Ran-independent mechanism for nuclear import of the U1A and U2B" spliceosome proteins.". J. Cell Biol. 148 (2): 293–303. PMC 2174293 . PMID 10648562. doi:10.1083/jcb.148.2.293.
Klein Gunnewiek JM, Hussein RI, van Aarssen Y, et al. (2000). "Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.". Mol. Cell. Biol. 20 (6): 2209–17. PMC 110837 . PMID 10688667. doi:10.1128/MCB.20.6.2209-2217.2000.
Varani L, Gunderson SI, Mattaj IW, et al. (2000). "The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein.". Nat. Struct. Biol. 7 (4): 329–35. PMID 10742179. doi:10.1038/74101.
Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.". EMBO J. 19 (23): 6569–81. PMC 305846 . PMID 11101529. doi:10.1093/emboj/19.23.6569.
Simmons A, Aluvihare V, McMichael A (2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.". Immunity. 14 (6): 763–77. PMID 11420046. doi:10.1016/S1074-7613(01)00158-3.

PDB gallery

1aud: U1A-UTRRNA, NMR, 31 STRUCTURES

1cx0: HEPATITIS DELTA VIRUS RIBOZYME

1drz: U1A SPLICEOSOMAL PROTEIN/HEPATITIS DELTA VIRUS GENOMIC RIBOZYME COMPLEX

1dz5: THE NMR STRUCTURE OF THE 38KDA U1A PROTEIN-PIE RNA COMPLEX REVEALS THE BASIS OF COOPERATIVITY IN REGULATION OF POLYADENYLATION BY HUMAN U1A PROTEIN

1fht: RNA-BINDING DOMAIN OF THE U1A SPLICEOSOMAL PROTEIN U1A117, NMR, 43 STRUCTURES

1m5k: Crystal structure of a hairpin ribozyme in the catalytically-active conformation

1m5o: Transition State Stabilization by a Catalytic RNA

1m5p: Transition State Stabilization by a Catalytic RNA

1m5v: Transition State Stabilization by a Catalytic RNA

1nu4: U1A RNA binding domain at 1.8 angstrom resolution reveals a pre-organized C-terminal helix

1oia: U1A RNP DOMAIN 1-95

1sj3: Hepatitis Delta Virus Gemonic Ribozyme Precursor, with Mg2+ Bound

1sj4: Crystal structure of a C75U mutant Hepatitis Delta Virus ribozyme precursor, in Cu2+ solution

1sjf: Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Cobalt Hexammine solution

1u6b: CRYSTAL STRUCTURE OF A SELF-SPLICING GROUP I INTRON WITH BOTH EXONS

1urn: U1A MUTANT/RNA COMPLEX + GLYCEROL

1vbx: Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in EDTA solution

1vby: Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, and Mn2+ bound

1vbz: Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Ba2+ solution

1vc0: Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Imidazole and Sr2+ solution

1vc5: Crystal Structure of the Wild Type Hepatitis Delta Virus Gemonic Ribozyme Precursor, in EDTA solution

1vc6: Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Product with C75U Mutaion, cleaved in Imidazole and Mg2+ solutions

1vc7: Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Sr2+ solution

1zzn: Crystal structure of a group I intron/two exon complex that includes all catalytic metal ion ligands.

2nz4: Structural investigation of the GlmS ribozyme bound to its catalytic cofactor

2oih: Hepatitis Delta Virus gemonic ribozyme precursor with C75U mutation and bound to monovalent cation Tl+

2oj3: Hepatitis Delta Virus ribozyme precursor structure, with C75U mutation, bound to Tl+ and cobalt hexammine (Co(NH3)63+)

2u1a: RNA BINDING DOMAIN 2 OF HUMAN U1A PROTEIN, NMR, 20 STRUCTURES

RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

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Small nuclear ribonucleoprotein polypeptide A

Interactions

References

Further reading