Ronald Ross

Sir Ronald Ross
Born (1857-05-13)13 May 1857
Almora, North-Western Provinces, British India
Died 16 September 1932(1932-09-16) (aged 75)
London, England, United Kingdom
Resting place Putney Vale Cemetery
51°26′18″N 0°14′23″W / 51.438408°N 0.239821°W / 51.438408; -0.239821
Nationality British
Fields Medicine
Institutions Presidency General Hospital, Calcutta
Liverpool School of Tropical Medicine
King's College Hospital
British War Office
Ministry of Pensions and National Insurance
Ross Institute and Hospital for Tropical Diseases
Alma mater St Bartholomew's Hospital Medical College
Society of Apothecaries
Known for Discovering that the malaria parasite is transmitted by mosquitoes
Notable awards
Author abbrev. (zoology) Ross
Spouse Rosa Bessie Bloxam (m. 1889)
Children 2 sons, 2 daughters

Sir Ronald Ross KCB KCMG FRS FRCS[1][2] (13 May 1857 – 16 September 1932), was a British medical doctor who received the Nobel Prize for Physiology or Medicine in 1902 for his work on the transmission of malaria, becoming the first British Nobel laureate, and the first born outside of Europe. His discovery of the malarial parasite in the gastrointestinal tract of a mosquito proved that malaria was transmitted by mosquitoes, and laid the foundation for the method of combating the disease. He was a polymath, writing a number of poems, published several novels, and composed songs. He was also an amateur artist and natural mathematician. He worked in the Indian Medical Service for 25 years. It was during his service that he made the groundbreaking medical discovery. After resigning from his service in India, he joined the faculty of Liverpool School of Tropical Medicine, and continued as Professor and Chairman of Tropical Medicine of the institute for 10 years. In 1926 he became Director-in-Chief of the Ross Institute and Hospital for Tropical Diseases, which was established in honour of his works. He remained there until his death.[3][4]

Early life and education

Ronald Ross was born in Almora, India, the eldest of ten children of Sir Campbell Claye Grant Ross, General in the British Indian Army, and Matilda Charlotte Elderton. At age eight he was sent to England to live with his aunt and uncle on the Isle of Wight. He attended Primary schools at Ryde, and for secondary education he was sent to a boarding school at Springhill, near Southampton, in 1869. From his early childhood he developed passion for poetry, music, literature and mathematics. At fourteen years of age he won a prize for mathematics, a book titled Orbs of Heaven which sparked his interest in mathematics. In 1873, at sixteen, he secured first position in the Oxford and Cambridge local examination in drawing.[5] Although he wanted to become a writer, his father arranged enrollment at St Bartholomew's Hospital Medical College in London, in 1874. Not fully committed, he spent most of his time composing music, and writing poems and plays. He left in 1880. In 1879 he had passed the examinations for the Royal College of Surgeons of England, and he worked as a ship's surgeon on a transatlantic steamship while studying for the licenciate of the Society of Apothecaries.[6] He qualified on second attempt in 1881, and after a four-month training at Army Medical School, he entered Indian Medical Service in 1881.[4] Between June 1888 and May 1889 he took study leave to obtain the Diploma in Public Health from the Royal College of Physicians and Royal College of Surgeons, and took a course in bacteriology under Professor E. E. Klein.[3]

Career

India

Ronald Ross embarked for India on 22 September 1881 on the troopship Jumma. Between 1881 and 1894 he was variously posted in Madras, Burma, Baluchistan, Andaman Islands, Bangalore and Secunderabad. In 1883, he was posted as the Acting Garrison Surgeon at Bangalore during which he noticed the possibility of controlling mosquitoes by limiting their access to water. In March 1894 he had his home leave and went to London with his family. On 10 April 1894 he met Sir Patrick Manson for the first time. Manson who became Ross's mentor, introduced him to the real problems in malaria research. Manson always had a firm belief that India was the best place for the study. Ross returned to India on P&O Ferries' Ballaarat on 20 March 1895 and landed in Secunderabad on 24 April.[7] Even before his luggage was cleared in the custom office, he went straight for Bombay Civil Hospital, looking for malarial patients and started making blood films.

Discovery of malaria vector

The page in Ross' notebook where he recorded the "pigmented bodies" in mosquitoes that he later identified as malaria parasites

Ross made his first important step in May 1895 when he observed the early stages of malarial parasite inside a mosquito stomach. However, his enthusiasm was interrupted as he was deployed to Bangalore to investigate an outbreak of cholera. Bangalore had no regular cases of malaria. He confided to Manson stating, "I am thrown out of employment and have 'no work to do'." But in April he had a chance to visit Sigur Ghat near the hill station of Ooty, where he noticed a mosquito on the wall in a peculiar posture, and for this he called it "dappled-winged" mosquito, not knowing the species. In May 1896, he was given a short leave that enabled him to visit a malaria-endemic region around Ooty. In spite of his daily quinine prophylaxis, he was down with severe malaria three days after his arrival. In June he was transferred to Secunderabad. After two years of research failure, in July 1897, he managed to culture 20 adult "brown" mosquitoes from collected larvae. He successfully infected the mosquitoes from a patient named Husein Khan for a price of 8 annas (one anna per blood-fed mosquito!). After blood-feeding, he dissected the mosquito and found an "almost perfectly circular" cell from the gut, which was certainly not of the mosquito. (This discovery was published in the 18 December 1897 issue of British Medical Journal.)[8][9] On 20 August he confirmed the presence of the malarial parasite inside the gut of mosquito, which he originally identified as "dappled-wings" (which turned out to be species of the genus Anopheles). The next day, on 21 August, he confirmed the growth of the parasite in the mosquito. In the evening he composed the following poem for his discovery (originally unfinished, sent to his wife on 22 August, and completed a few days later):[10][11]

This day relenting God
Hath placed within my hand
A wondrous thing; and God
Be praised. At His command,
Seeking His secret deeds
With tears and toiling breath,
I find thy cunning seeds,
O million-murdering Death.
I know this little thing
A myriad men will save.
O Death, where is thy sting?
Thy victory, O Grave?

Discovery of malaria transmission

Ross, Mrs Ross, Mahomed Bux, and two other assistants at Cunningham’s laboratory of Presidency Hospital in Calcutta

In September 1897, Ross was transferred to Bombay, from where he was subsequently sent to a malaria-free Kherwara in Rajputana (now Rajasthan). Frustrated of lack of work he threatened to resign from service as he felt that it was a death blow to his pursuit. It was only on the representation of Patrick Manson, that the government arranged for his continued service in Calcutta on a "special duty".[3] On 17 February 1898 he arrived in Calcutta (now Kolkata), to work in the Presidency General Hospital.[12] He immediately carried out research in malaria and kala azar, for which he was assigned. He was given the use of Surgeon-Lieutenant-General Cunningham’s laboratory for his research. He had no success with malarial patients because they were always immediately given medication. He built a bungalow with a laboratory at Mahanad village, where he would stay from time to time to collect mosquitoes in and around the village. He employed Mahomed (or Muhammed) Bux, Purboona (who deserted him after the first payday), and Kishori Mohan Bandyopadhyay as laboratory assistants. As Calcutta was not a malarious place, Manson persuaded him to use birds, as being used by other scientists such as Vasily Danilewsky in Russia and William George MacCallum in America. Ross complied but with a complaint that he "did not need to be in India to study bird malaria". By March he began to see results on bird parasites, very closely related to the human malarial parasites.[13] Using more convenient model of birds, by July 1898 he established the importance of mosquitoes as intermediate hosts in avian malaria. On 4 July he discovered that the salivary gland was the storage sites of malarial parasites in the mosquito. By 8 July he was convinced that the parasites are released from the salivary gland during biting. He later demonstrated the transmission of malarial parasite from mosquitoes (in this case Culex species) to healthy birds from an infected one, thus, establishing the complete life cycle of malarial parasite.[14][15][16][17][18][19]

In September 1898 he went to southern Assam in (northeast India) to study an epidemic of kala azar. He was invited to work there by Dr Graham Col Ville Ramsay, the second Medical Officer of the Labac Tea Estate Hospital. (His microscope and medicals tools are still preserved, and his sketches of mosquitoes are still on display at the hospital.)[20] However, he utterly failed as he believed that the kala azar parasite (Leishmania donovani, the very scientific name he later gave in 1903) was transmitted by a mosquito, which he refers to as Anopheles rossi. (It is now known that kala azar is transmitted by sandflies.)

England

Blue plaque, 18 Cavendish Square, London

In 1899, Ross resigned from Indian Medical Service and went to England to join the faculty of the Liverpool School of Tropical Medicine as lecturer. He continued to work on prevention of malaria in different parts of the world, including West Africa, the Suez Canal zone,[21] Greece, Mauritius, Cyprus, and in the areas affected by the First World War. He also initiated organisations, which proved to be well established, for fighting malaria in India and Sri Lanka. He was appointed as Professor and Chair of Tropical Medicine of the Liverpool School of Tropical Medicine in 1902, which he held up to 1912. In 1912 he was appointed Physician for Tropical Diseases at King's College Hospital in London, and simultaneously hold the Chair of Tropical Sanitation in Liverpool. He remained in these posts until 1917 when he became (honorary) Consultant in Malariology in British War Office. He travelled to Thessaloniki and Italy in November to advise and on the way, "in a landlocked bay close to the Leucadian Rock (where Sappho is supposed to have drowned hers)", his ship escaped a torpedo attack.[22] Between 1918 and 1926 he worked as Consultant in Malaria in the Ministry of Pensions and National Insurance.

Ross developed mathematical models for the study of malaria epidemiology, which he initiated in his report on Mauritius in 1908. He elaborated the concept in his book The Prevention of malaria in 1910[23] (2nd edition in 1911) and further elaborated in a more generalised form in scientific papers published by the Royal Society in 1915 and 1916. These papers represented a profound mathematical interest which was not confined to epidemiology, but led him to make material contributions to both pure and applied mathematics.

Ross Institute and Hospital for Tropical Diseases

The Ross Institute and Hospital for Tropical Diseases was founded in 1926 and established at Bath House, a grand house with keeper's lodge and large grounds adjacent to Tibbet's Corner at Putney Heath. The hospital was opened by the then Prince of Wales, the future King Edward VIII.[24] Ross assumed the post of Director-in-Chief until his death.[6] The institute was later incorporated into the London School of Hygiene & Tropical Medicine in Keppel Street. Bath House was later demolished and mansion flats built on the property. In memory of its history and owner the block was named Ross Court. Within the grounds an older dwelling, Ross Cottage, remains.

Nobel Prize controversy

Ronald Ross

Ronald Ross was awarded a Nobel Prize for his discovery of the life cycle of malarial parasite. He did not build his concept of malarial transmission in humans, but in birds.[2] In 1897, an Italian physician and zoologist Giovanni Battista Grassi, along with his colleagues, had established the developmental stages of malaria parasites in anopheline mosquitoes; and they described the complete life cycles of P. falciparum, P. vivax and P. malariae the following year.[25][26] When the 1902 Nobel Prize for Physiology or Medicine was considered, the Nobel Committee initially intended the prize to be shared between Ross and Grassi, however Ross accused Grassi of deliberate fraud. The weight of favour ultimately fell on Ross, largely due to the influences of Robert Koch, the appointed neutral arbitrator in the committee; as reported, "Koch threw the full weight of his considerable authority in insisting that Grassi did not deserve the honor".[27] Ross was the first to show that malarial parasite was transmitted by the bite of infected mosquitoes, in his case the avian Plasmodium relictum.

Personal life and death

Ronald Ross was noted to be eccentric and egocentric, described as an "impulsive man". His professional life appeared to be in constant feud with his students, colleagues and fellow scientists.[28] His personal vendetta with G.B. Grassi became a legendary tale in science. He was openly envious of his mentor Patrick Manson's affluence from private practices. This was largely due to his own ineptitude to compete with other physicians. His Memories of Sir Patrick Manson (1930) was a direct attempt to belittle Manson's influences on his works on malaria.[7] He hardly had good ties with the administration of Liverpool School of Tropical Medicine, complaining of being underpaid. He resigned twice, and was eventually discharged without any pension.[29]

A horizontal gravestone, badly dilapidated and with grass growing among the cracks
Ross's grave at Putney Vale Cemetery, London in 2014

Ross was frequently embittered by lack of government support (what he called "administrative barbarism")[4] for scientists in medical research. In 1928 he advertised his papers for sale in Science Progress, with a statement that the money was for financial support of his wife and family. Lady Houston bought them for £2000, and offered them to the British Museum, which turned her down for various reasons. The papers are now preserved by the London School of Hygiene and Tropical Medicine[3][30] and the Royal College of Physicians and Surgeons of Glasgow.[31]

Ross married Rosa Bessie Bloxam in 1889. They had two daughters, Dorothy (1891–1947) and Sylvia (1893–1925), and two sons, Ronald Campbell (1895–1914) and Charles Claye (1901–1966). His wife died in 1931. Ronald and Sylvia pre-deceased him too: Ronald was killed at the Battle of Le Cateau on 26 August 1914.[32] Ross died at the hospital of his namesake after a long illness and asthma attack. He was buried at the nearby Putney Vale Cemetery, next to his wife.[33][34][35]

Legacy

Ronald Ross Memorial, Calcutta

Ronald Ross Memorial, SSKM Hospital, Kolkata

A small memorial on the walls of SSKM Hospital commemorates Ross' discovery. The memorial was unveiled by Ross himself, in the presence of Lord Lytton, on 7 January 1927.[36]

Books

Literary works

Ross was a prolific writer. He habitually wrote poems on most of the important events in his life. His poetic works gained him wide acclaim and they reflect his medical service, travelogue, philosophical and scientific thoughts. Many of his poems are collected in his Selected Poems (1928) and In Exile (1931). Some of his notable books are The Child of Ocean (1899 and 1932), The Revels of Orsera, The Spirit of Storm, Fables and Satires (1930), Lyra Modulatu (1931), and five mathematical works (1929–1931). He also compiled an extensive account The Prevention of Malaria in 1910 and another Studies on Malaria in 1928. He published his autobiography Memoirs, with a Full Account of the Great Malaria Problem and its Solution (547 pages long) in 1923. He carefully saved virtually everything about himself: correspondence, telegrams, newspaper cuttings, drafts of published and unpublished material, and all manner of ephemera.[4]

Awards and recognition

Plaque at Liverpool University – on the Johnston Building, formerly the Johnston Laboratories, near Ashton Street, Liverpool
Ross's name remembered on the London School of Hygiene and Tropical Medicine

Ronald Ross was awarded the Nobel Prize for Physiology or Medicine in 1902 "for his work on malaria, by which he has shown how it enters the organism and thereby has laid the foundation for successful research on this disease and methods of combating it".[37]

The 20 August is celebrated by London School of Hygiene & Tropical Medicine as World Mosquito Day to commemorate Ross' discovery in 1897.[38] Additionally, Ross' name, along with 22 other pioneers of public health and tropical medicine, appears on the School's Frieze.[39]

He was elected a Fellow of the Royal Society (FRS) in 1901 and of the Royal College of Surgeons in the same year. He was appointed Vice-President of the Royal Society from 1911 to 1913. In 1902 he was appointed a Companion of the Most Honourable Order of the Bath by King Edward VII. In 1911 he was promoted to the rank of Knight Commander of the same Order. He was also decorated with the title Officer of the Order of Leopold II of Belgium.

Ross received honorary membership of learned societies of most countries in Europe, and elsewhere. He got an honorary M.D. degree in Stockholm in 1910 at the centenary celebration of the Caroline Institute and his 1923 autobiography Memoirs was awarded that year's James Tait Black Memorial Prize. While his vivacity and single-minded search for truth caused friction with some people, he enjoyed a vast circle of friends in Europe, Asia and the United States who respected him for his personality as well as for his genius.

In India, Ross is remembered with great respect as a result of his work on malaria, the deadly epidemic which used to claim thousands of lives every year. There are roads named after him in many Indian towns and cities. In Calcutta the road linking Presidency General Hospital with Kidderpore Road has been renamed after him as Sir Ronald Ross Sarani. Earlier this road was known as Hospital Road. In his memory, the regional infectious disease hospital at Hyderabad was named Sir Ronald Ross Institute of Tropical and Communicable Diseases. The building where he worked and actually discovered the malarial parasite, located in Secunderabad near the Begumpet Airport, is a declared a heritage site and the road leading up to the building is named Sir Ronald Ross Road.

In Ludhiana, Christian Medical College has named its hostel as "Ross Hostel". The young medics often refer to themselves as "Rossians".

The University of Surrey, UK, has named a road after him in its Manor Park Residences.[40]

Ronald Ross primary school near Wimbledon Common is named after him. The school's coat of arms includes a mosquito in one quarter.[41]

Sir Ronald Ross Institute of Parasitology was established in memory of Ronald Ross in Hyderabad, under Osmania University.[42]

In 2010 the University of Liverpool has named its new biological science building "The Ronald Ross Building" in his honour. His grandson David Ross inaugurated it. The building is home to the university's facility for the Institute of Infection and Global Health.[43]

See also

References

  1. 1 2 N., G. H. F. (1933). "Sir Ronald Ross. 1857–1932". Obituary Notices of Fellows of the Royal Society. 1 (2): 108–115. doi:10.1098/rsbm.1933.0006.
  2. 1 2 Rajakumar, K; Weisse, M (1999). "Centennial year of Ronald Ross' epic discovery of malaria transmission: an essay and tribute.". Southern Medical Journal. 92 (6): 567–71. PMID 10372849. doi:10.1097/00007611-199906000-00004.
  3. 1 2 3 4 "Ross and the Discovery that Mosquitoes Transmit Malaria Parasites". Centers for Disease Control and Prevention. 8 February 2010. Retrieved 31 January 2014.
  4. 1 2 3 4 "Sir Ronald Ross (1857–1932)". Dr. B.S. Kakkilaya's Malaria Web Site. Retrieved 31 January 2014.
  5. ↑ Ross, Sir Ronald (1923). Memoirs with a full account of The Great Malaria Problem and its Solution. Albemarle Street, W. London: John Murray. p. 24.
  6. 1 2 "Biography of Sir Ronald Ross". London School of Hygiene & Tropical Medicine. Retrieved 31 January 2014.
  7. 1 2 Lavery, Marck Bryan. "Malaria Wars Episode MDCCCXCVIII: Ronald Ross and the Great Malaria Problem" (PDF). evolve360. Retrieved 9 February 2014.
  8. ↑ Ross, R (1897). "On some Peculiar Pigmented Cells Found in Two Mosquitos Fed on Malarial Blood". British Medical Journal. 2 (1929): 1786–8. PMC 2408186 Freely accessible. PMID 20757493. doi:10.1136/bmj.2.1929.1786.
  9. ↑ Sinden, Robert E. "Malaria, mosquitoes and the legacy of Ronald Ross". World Health Organization. Retrieved 31 January 2014.
  10. ↑ Scott, M. P. (2007). "Developmental genomics of the most dangerous animal". Proceedings of the National Academy of Sciences USA. 104 (29): 11865–11866. PMC 1924572 Freely accessible. PMID 17620616. doi:10.1073/pnas.0704795104.
  11. ↑ Mackay, Alan L. (2001) [1977]. A Dictionary of Scientific Quotations (2, Reprinted ed.). Bristol: IOP Publishing Ltd. pp. 209–210. ISBN 9780750301060.
  12. ↑ Dutta, A. (2009). "Where Ronald Ross (1857–1932) worked: the discovery of malarial transmission and the Plasmodium life cycle". Journal of Medical Biography. 17 (2): 120–122. PMID 19401518. doi:10.1258/jmb.2009.009004.
  13. ↑ Ross, Ronald (1898). Report on the cultivation of protesoma, Labbé, in grey mosquitoes. Calcutta: Superintendent of Govt. Printing. pp. 1–2.
  14. ↑ Katz, FF (1997). "On the centenary of Sir Ronald Ross's discovery of the role of the mosquito in the life cycle of the malaria parasite.". Journal of Medical Biography. 5 (4): 200–4. PMID 11619711. doi:10.1177/096777209700500403.
  15. ↑ Bynum, WF (1999). "Ronald Ross and the malaria-mosquito cycle.". Parassitologia. 41 (1–3): 49–52. PMID 10697833.
  16. ↑ Dutta, A (2009). "Where Ronald Ross (1857–1932) worked: the discovery of malarial transmission and the Plasmodium life cycle.". Journal of Medical Biography. 17 (2): 120–2. PMID 19401518. doi:10.1258/jmb.2009.009004.
  17. ↑ Cook, GC (1997). "Ronald Ross (1857–1932): 100 years since the demonstration of mosquito transmission of Plasmodium spp—on 20 August 1897.". Transactions of the Royal Society of Tropical Medicine and Hygiene. 91 (4): 487–8. PMID 9373663. doi:10.1016/s0035-9203(97)90295-9.
  18. ↑ Capanna E (2012). "Grassi versus Ross: who solved the riddle of malaria?". International Microbiology. 9 (1): 69–74. PMID 16636993.
  19. ↑ Sherman, Irwin (2008). Reflections on a century of malaria biochemistry. London: Academic. p. 5. ISBN 978-0080-9-2183-9.
  20. ↑ "Laboc Hospital – A Noble Prize Winner's Workplace". easternpanorama.in. Retrieved 11 July 2013.
  21. ↑ "My experiences in Panama / Sir Ronald Ross 1916". National Library of Medicine.
  22. ↑ [G. H. F. N.] (1933). "Sir Ronald Ross. 1857-1932". Obituary Notices of Fellows of the Royal Society. 1 (2): 108–115. JSTOR 768746. doi:10.1098/rsbm.1933.0006.
  23. ↑ Ross, Ronald (1910). The Prevention of Malaria.
  24. ↑ "1920 History Timeline | London School of Hygiene & Tropical Medicine | LSHTM". Timeline.lshtm.ac.uk. Retrieved 2 December 2012.
  25. ↑ Baccetti B (2008). "History of the early dipteran systematics in Italy: from Lyncei to Battista Grassi". Parassitologia. 50 (3–4): 167–172. PMID 20055226.
  26. ↑ Cox, Francis E.G. (2010). "History of the discovery of the malaria parasites and their vectors". Parasites & Vectors. 3 (1): 5. PMC 2825508 Freely accessible. PMID 20205846. doi:10.1186/1756-3305-3-5.
  27. ↑ Esch GW (2007). Parasites and Infectious Disease: Discovery by Serendipity and Otherwise. Cambridge University Press. pp. 137–138. ISBN 978-1-1394-6-4109.
  28. ↑ McCallum, Jack E. (2007). Military Medicine: From Ancient Times to the 21st Century (1st ed.). Santa Barbara: Abc-Clio. pp. 273–274. ISBN 978-1-8510-9693-0.
  29. ↑ W. F. Bynum. "Ronald Ross: Malariologist and Polymath: A Biography". Project MUSE. Retrieved 9 February 2014.
  30. ↑ "Introduction to the Ross Collection | London School of Hygiene & Tropical Medicine | LSHTM.". www.lshtm.ac.uk. Retrieved 2017-03-21.
  31. ↑ "Ross, Sir Ronald (1857–1932), surgeon : GB 250 RCPSG 9". Retrieved 17 November 2016.
  32. ↑ Sherborne School Book of Remembrance on Flickr
  33. ↑ "Ronald Ross". NNDB. Retrieved 13 December 2014.
  34. ↑ "RONALD ROSS (1857-1932)". zephyrus. Retrieved 13 December 2014.
  35. ↑ Cook, GC (1999). "The grave of Sir Ronald Ross FRS (1857–1932)". The Lancet. 354 (9184): 1128. PMID 10509539. doi:10.1016/S0140-6736(05)76928-2.
  36. ↑ Our Bureau (4 July 2014). "Malaria Poser Sting in Court". The Telegraph. Retrieved 28 February 2015.
  37. ↑ "Ronald Ross – Facts". Nobel Media AB. Retrieved 31 January 2014.
  38. ↑ "World Mosquito Day". Malaria No More UK. Retrieved 31 January 2014.
  39. ↑ "Behind the Frieze | London School of Hygiene & Tropical Medicine | LSHTM.". www.lshtm.ac.uk. Retrieved 2017-03-21.
  40. ↑ "Manor Park Residences" (PDF). University of Surrey.
  41. ↑ "Ronald Ross Primary School – Home". Ronaldross.org.uk. 22 November 2012. Retrieved 2 December 2012.
  42. ↑ "Sir Ronald Ross Institute Of Parasitoloy". Osmania.ac.in. Retrieved 2 December 2012.
  43. ↑ "Opening of The Ronald Ross Building". Institute of Infection and Global Health, University of Liverpool. 10 October 2010. Retrieved 31 January 2014.

Further reading

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