Signaling lymphocytic activation molecule
Signaling lymphocytic activation molecule is a family of genes. Homophilic binding between SLAMs is involved in cellular adhesion [1][2]
Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells. SLAM is a self ligand and enhances T cellular proliferation and IFN-gamma production.
A defective SLAM associated protein (SAP) causes X-linked lymphoproliferative syndrome (XLP), a frequently lethal mononucleosis based on the inability to control EBV
Members of the family include:
- SLAMF1 (CD150)
- SLAMF2 (CD48)[3]
- SLAMF3 (CD229, LY9)
- SLAMF4 (CD244)
- SLAMF5 (CD84)
- SLAMF6 (CD352)[4]
- SLAMF7 (CD319)[5]
- SLAMF8 (CD353)[6]
- SLAMF9[7]
References
- ↑ "SLAM FAMILY, MEMBER 1". OMIM. Retrieved 19 March 2014.
- ↑ Rosenbach, T; Csatò, M; Czarnetzki, B. M. (1988). "Studies on the role of leukotrienes in murine allergic and irritant contact dermatitis". The British Journal of Dermatology. 118 (1): 1–6. PMID 2829957. doi:10.1111/j.1365-2133.1988.tb01743.x.
- ↑ Sintes, J; Engel, P (2011). "SLAM (CD150) is a multitasking immunoreceptor: From cosignalling to bacterial recognition". Immunology and cell biology. 89 (2): 161–3. PMID 21102539. doi:10.1038/icb.2010.145.
- ↑ Chatterjee, M.; Kis-Toth, K.; Thai, TH.; Terhorst, C.; Tsokos, GC. (May 2011). "SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells.". Autoimmunity. 44 (3): 211–8. PMC 4465387 . PMID 21231893. doi:10.3109/08916934.2010.530627.
- ↑ Kim, JR; Horton, NC; Mathew, SO; Mathew, PA (2013). "CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes". Inflammation Research. 62 (8): 765–72. PMID 23695528. doi:10.1007/s00011-013-0632-1.
- ↑ Wang, G; Abadía-Molina, AC; Berger, SB; Romero, X; O'Keeffe, MS; Rojas-Barros, DI; Aleman, M; Liao, G; et al. (2012). "Cutting edge: Slamf8 is a negative regulator of Nox2 activity in macrophages". Journal of immunology (Baltimore, Md. : 1950). 188 (12): 5829–32. PMC 3370125 . PMID 22593622. doi:10.4049/jimmunol.1102620.
- ↑ Pott, S.; Kamrani, N. K.; Bourque, G.; Pettersson, S.; Liu, E. T. (2012). Jothi, Raja, ed. "PPARG Binding Landscapes in Macrophages Suggest a Genome-Wide Contribution of PU.1 to Divergent PPARG Binding in Human and Mouse". PLoS ONE. 7 (10): e48102. PMC 3485280 . PMID 23118933. doi:10.1371/journal.pone.0048102.
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