Serrate RNA effector molecule homolog

SRRT

Identifiers

SRRT, ARS2, ASR2, serrate, serrate, RNA effector molecule

External IDs

MGI: 1933527 HomoloGene: 9298 GeneCards: SRRT

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	No data available	Start	100,875,111 bp^[1]
Band	No data available	End	100,888,664 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	No data available	Start	137,295,704 bp^[2]
Band	No data available	End	137,307,674 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• DNA binding • protein binding • nucleic acid binding • RNA binding
Cellular component	• cytoplasm • nucleus • nucleoplasm • protein complex
Biological process	• positive regulation of neurogenesis • gene silencing by RNA • cell proliferation • regulation of transcription, DNA-templated • response to arsenic-containing substance • transcription, DNA-templated • neuronal stem cell population maintenance • primary miRNA processing • mRNA splicing, via spliceosome • snRNA transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51593


83701

Ensembl


ENSG00000087087


ENSMUSG00000037364

UniProt


Q9BXP5


Q99MR6

RefSeq (mRNA)


NM_001128852 NM_001128853 NM_001128854 NM_015908 NM_182800


NM_001109909 NM_001109910 NM_031405

RefSeq (protein)


NP_001122324 NP_001122325 NP_001122326 NP_056992


NP_001103379 NP_001103380 NP_113582

Location (UCSC)

Chr 7: 100.88 – 100.89 Mb

Chr 7: 137.3 – 137.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.^[5]

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding the SOX2 promoter and positively regulating its transcription.

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000087087 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037364 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: ARS2 ARS2 protein".

Rossman TG, Wang Z (1999). "Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis.". Carcinogenesis. 20 (2): 311–6. PMID 10069470. doi:10.1093/carcin/20.2.311.
Wilson MD, Riemer C, Martindale DW, et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.". Nucleic Acids Res. 29 (6): 1352–65. PMC 29746 . PMID 11239002. doi:10.1093/nar/29.6.1352.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science. 300 (5620): 767–72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.". J. Biochem. 133 (6): 713–8. PMID 12869526. doi:10.1093/jb/mvg091.
Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells. 9 (2): 105–20. PMID 15009096. doi:10.1111/j.1365-2443.2004.00705.x.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.
Szafranski K, Schindler S, Taudien S, et al. (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biology. 8 (8): R154. PMC 2374985 . PMID 17672918. doi:10.1186/gb-2007-8-8-r154.

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Serrate RNA effector molecule homolog

References

Further reading