Selenophosphate synthetase 1

SEPHS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FD5, 3FD6
Identifiers
Aliases	SEPHS1, SELD, SPS, SPS1, Selenophosphate synthetase 1
External IDs	MGI: 1923580 HomoloGene: 56558 GeneCards: SEPHS1
Gene location (Human) Chr. Chromosome 10 (human)[1] Band No data available Start 13,317,424 bp[1] End 13,348,298 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band No data available Start 4,881,564 bp[2] End 4,910,557 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • selenide, water dikinase activity • GTP binding • protein binding • ATP binding • protein homodimerization activity • identical protein binding • protein heterodimerization activity • kinase activity Cellular component • cytoplasm • plasma membrane • nuclear membrane • membrane • nucleus Biological process • cellular protein modification process • phosphorylation • selenocysteine biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22929	109079
Ensembl	ENSG00000086475	ENSMUSG00000026662
UniProt	P49903 Q5T5U7	Q8BH69
RefSeq (mRNA)	NM_001195602 NM_001195604 NM_012247	NM_175400
RefSeq (protein)	NP_001182531 NP_001182533 NP_036379	NP_780609
Location (UCSC)	Chr 10: 13.32 – 13.35 Mb	Chr 10: 4.88 – 4.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.^[5][6]

This protein encodes an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.^[6]

References

Further reading