Plunc

BPIFA1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBPIFA1, LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5, BPI fold containing family A member 1
External IDsOMIM: 607412 MGI: 1338036 HomoloGene: 7895 GeneCards: BPIFA1
Gene location (Human)
Chr.Chromosome 20 (human)[1]
BandNo data availableStart33,235,995 bp[1]
End33,243,311 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51297

18843

Ensembl

ENSG00000198183

ENSMUSG00000027483

UniProt

Q9NP55

P97361

RefSeq (mRNA)

NM_001243193
NM_016583
NM_130852

NM_011126

RefSeq (protein)

NP_001230122
NP_057667
NP_570913

NP_035256

Location (UCSC)Chr 20: 33.24 – 33.24 MbChr 20: 154.14 – 154.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Palate, lung, and nasal epithelium clone protein[5] (PLUNC) is a gene encoding a secretory protein. It is also called Secretory protein in upper respiratory tracts (SPURT). In humans, it is encoded by the BPIFA1 gene, previously called PLUNC.[6][7]

Function

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the airways and nasopharyngeal regions. Plunc inhibits the epithelial sodium channel (ENaC),[8] and also has anti-microbial functions.[9] As such, plunc is believed to play a role in innate immune defense in the airways. PLUNC's ability to regulate ENaC is pH-sensitive and fails in acidic cystic fibrosis airways.[10] Thus, defective PLUNC1 function is thought to contribute to the development of lung pathology in cystic fibrosis patients.

It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer.[11]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198183 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027483 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Ghafouri, B. "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid". Biochem Soc Trans. 31: 810–4. PMID 12887311. doi:10.1042/bst0310810.
  6. ↑ Bingle CD, Bingle L (Oct 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica et Biophysica Acta. 1493 (3): 363–7. PMID 11018263. doi:10.1016/S0167-4781(00)00196-2.
  7. ↑ Iwao K, Watanabe T, Fujiwara Y, Takami K, Kodama K, Higashiyama M, Yokouchi H, Ozaki K, Monden M, Tanigami A (Feb 2001). "Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer". International Journal of Cancer. Journal International Du Cancer. 91 (4): 433–7. PMID 11251963. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1059>3.0.CO;2-B.
  8. ↑ Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, Donaldson SH, Stutts MJ, Tarran R (Jul 2009). "SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage". Proceedings of the National Academy of Sciences of the United States of America. 106 (27): 11412–7. PMC 2708735 Freely accessible. PMID 19541605. doi:10.1073/pnas.0903609106.
  9. ↑ 6
  10. ↑ Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R (Oct 2013). "Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways". Proceedings of the National Academy of Sciences of the United States of America. 110 (40): 15973–8. PMC 3791714 Freely accessible. PMID 24043776. doi:10.1073/pnas.1311999110.
  11. ↑ "Entrez Gene: PLUNC".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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