SYT7
Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.[5][6]
Function
Synaptotagmins, such as SYT7, are brain-specific calcium-dependent phospholipid-binding proteins that play a role in synaptic exocytosis and neurotransmitter release. See MIM 600782.[supplied by OMIM][6]
Interactions
SYT7 has been shown to interact with SYNCRIP.[7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000011347 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024743 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB (May 1998). "Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes". Genomics. 49 (3): 419–29. PMID 9615227. doi:10.1006/geno.1998.5291.
- 1 2 "Entrez Gene: SYT7 synaptotagmin VII".
- ↑ Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. PMID 10734137. doi:10.1074/jbc.275.13.9823.
Further reading
- Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC (June 1995). "Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins". Nature. 375 (6532): 594–9. PMID 7791877. doi:10.1038/375594a0.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
- Perin MS (October 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. PMID 8901523. doi:10.1021/bi960853x.
- Craxton M, Goedert M (November 1999). "Alternative splicing of synaptotagmins involving transmembrane exon skipping". FEBS Letters. 460 (3): 417–22. PMID 10556508. doi:10.1016/S0014-5793(99)01382-4.
- Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T (December 1999). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes". Genome Research. 9 (12): 1198–203. PMC 310991
. PMID 10613842. doi:10.1101/gr.9.12.1198. - Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. PMID 10734137. doi:10.1074/jbc.275.13.9823.
- Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW (May 2001). "The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi". The Journal of Experimental Medicine. 193 (9): 1097–104. PMC 2193425 . PMID 11342594. doi:10.1084/jem.193.9.1097.
- Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K (July 2002). "Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human". The Biochemical Journal. 365 (Pt 1): 173–80. PMC 1222667 . PMID 12071850. doi:10.1042/BJ20011877.
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