SURF6

SURF6

Identifiers

SURF6, RRP14, surfeit 6

External IDs

MGI: 98447 HomoloGene: 133981 GeneCards: SURF6

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	No data available	Start	133,328,774 bp^[1]
Band	No data available	End	133,336,398 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	No data available	Start	26,888,628 bp^[2]
Band	No data available	End	26,902,879 bp^[2]

Gene ontology
Molecular function	• DNA binding • protein binding • RNA binding
Cellular component	• nucleolus • nucleus • nucleoplasm • granular component • cytosolic large ribosomal subunit
Biological process	• ribosome biogenesis • ribosomal large subunit biogenesis • ribosomal small subunit biogenesis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


6838


20935


ENSG00000148296 ENSG00000281309


ENSMUSG00000036160


O75683


P70279

RefSeq (mRNA)


NM_001278942 NM_006753


NM_009298

RefSeq (protein)


NP_001265871 NP_006744


NP_033324

Location (UCSC)

Chr 9: 133.33 – 133.34 Mb

Chr 9: 26.89 – 26.9 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene.^[5]^[6]

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.^[6]

References

1 2 3 ENSG00000281309 GRCh38: Ensembl release 89: ENSG00000148296, ENSG00000281309 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036160 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Duhig T, Ruhrberg C, Mor O, Fried M (May 1999). "The human Surfeit locus". Genomics. 52 (1): 72–8. PMID 9740673. doi:10.1006/geno.1998.5372.
1 2 "Entrez Gene: SURF6 surfeit 6".

Further reading

Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1.". Hum. Mol. Genet. 2 (3): 237–40. PMID 8499913. doi:10.1093/hmg/2.3.237.
Magoulas C, Fried M (1996). "The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein.". DNA Cell Biol. 15 (4): 305–16. PMID 8639267. doi:10.1089/dna.1996.15.305.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Magoulas C, Zatsepina OV, Jordan PW, et al. (1998). "The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro.". Eur. J. Cell Biol. 75 (2): 174–83. PMID 9548374. doi:10.1016/s0171-9335(98)80059-9.
Magoulas C, Fried M (2000). "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus.". Gene. 243 (1–2): 115–23. PMID 10675619. doi:10.1016/S0378-1119(99)00551-X.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298. doi:10.1016/S0960-9822(01)00650-9.
Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. PMID 11891058. doi:10.1016/S0378-1119(02)00379-7.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. PMID 15635413. doi:10.1038/nature03207.

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