SULT1C3

SULT1C3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSULT1C3, ST1C3, sulfotransferase family 1C member 3
External IDsMGI: 102928 HomoloGene: 56817 GeneCards: SULT1C3
Gene location (Human)
Chr.Chromosome 2 (human)[1]
BandNo data availableStart108,247,195 bp[1]
End108,265,351 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

442038

20888

Ensembl

ENSG00000196228

ENSMUSG00000023943

UniProt

Q6IMI6

Q80VR3

RefSeq (mRNA)

NM_001008743
NM_001320878

NM_018751

RefSeq (protein)

NP_001008743
NP_001307807

NP_061221

Location (UCSC)Chr 2: 108.25 – 108.27 MbChr 2: 53.96 – 53.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.[5][6][7]

Function

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.[5]

Clinical significance

ST1C3 sulfates large benzylic alcohols such as 1-hydroxymethyl-pyrene to chemically reactive mutagenic sulpho conjugates.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000196228 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023943 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: sulfotransferase family".
  6. ↑ Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. PMID 14676822. doi:10.1038/sj.tpj.6500223.
  7. ↑ Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLoS Biol. 5 (5): e97. PMC 1847840 Freely accessible. PMID 17425406. doi:10.1371/journal.pbio.0050097.
  8. ↑ Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. PMID 17936463. doi:10.1016/j.fct.2007.08.040.


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