STK17A

Identifiers

STK17A, DRAK1, serine/threonine kinase 17a

External IDs

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	No data available	Start	43,582,758 bp^[1]
Band	No data available	End	43,626,786 bp^[1]

Gene ontology
Molecular function	• kinase activity • transferase activity • nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • ATP binding
Cellular component	• nucleus • plasma membrane • nuclear speck
Biological process	• positive regulation of apoptotic process • positive regulation of fibroblast apoptotic process • protein phosphorylation • intracellular signal transduction • regulation of reactive oxygen species metabolic process • phosphorylation • apoptotic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9263


n/a

Ensembl


ENSG00000164543


n/a

UniProt


Q9UEE5


n/a

RefSeq (mRNA)


NM_004760


n/a

RefSeq (protein)


NP_004751


n/a

Location (UCSC)

Chr 7: 43.58 – 43.63 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.^[3]

Function

This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.^[3]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164543 - Ensembl, May 2017
↑ "Human PubMed Reference:".
1 2 "Entrez Gene: Serine/threonine kinase 17a".

Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, Pita G, Milne R, Maravall J, Ramos I, Andía V, Rodríguez-Poyo P, Jara-Albarrán A, Meoro A, del Peso C, Arribas L, Iglesias P, Caballero J, Serrano J, Picó A, Pomares F, Giménez G, López-Mondéjar P, Castello R, Merante-Boschin I, Pelizzo MR, Mauricio D, Opocher G, Rodríguez-Antona C, González-Neira A, Matías-Guiu X, Santisteban P, Robledo M (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLoS Genetics. 5 (9): e1000637. PMC 2727793 . PMID 19730683. doi:10.1371/journal.pgen.1000637.
Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. PMID 9786912. doi:10.1074/jbc.273.44.29066.
Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. PMC 3103316 . PMID 21489989. doi:10.1074/jbc.M111.218040.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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STK17A

Function

References

Further reading