STARD7

STARD7
Identifiers
AliasesSTARD7, GTT1, StAR related lipid transfer domain containing 7
External IDsMGI: 2139090 HomoloGene: 32463 GeneCards: STARD7
Gene location (Human)
Chr.Chromosome 2 (human)[1]
BandNo data availableStart96,184,859 bp[1]
End96,208,825 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

56910

99138

Ensembl

ENSG00000084090

ENSMUSG00000027367

UniProt

Q9NQZ5

Q8R1R3

RefSeq (mRNA)

NM_020151
NM_139267

NM_139308

RefSeq (protein)

NP_064536

NP_647469

Location (UCSC)Chr 2: 96.18 – 96.21 MbChr 2: 127.27 – 127.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

StAR-related lipid transfer domain protein 7 (STARD7) or gestational trophoblastic tumor gene-1 (GTT1) is a lipid transporter that specifically binds and transports phosphatidylcholine between membranes.[5]

Function and tissue distribution

StarD7 is found in the cytosol and associated with the mitochondrion.[5] When overproduced in the cell, mitochondrial levels of phosphatidylcholine rise.[5] High levels of the protein are found in tumor cells compared to normal cells, suggesting a role in cell proliferation.[6]

Structure

There are two forms of StarD7: StarD7-I and StarD7-II. The former is 295 amino acids long. StarD7-I possesses an additional 75 amino acids at its amino-terminus, which form a signaling sequence that targets it to the outer membrane of the mitochondrion.[5]

StarD7 contains a StAR-related transfer domain (START), from which it derives its name. Moreover, the protein is a member of the predominantly phosphatidylcholine transporter subfamily of START proteins, the StarD2 subfamily. It shares 25% sequence identity with StarD2.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000084090 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027367 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 3 4 5 Horibata Y, Sugimoto H (March 2010). "StarD7 mediates the intracellular trafficking of phosphatidylcholine to mitochondria". The Journal of Biological Chemistry. 285 (10): 7358–65. PMC 2844184 Freely accessible. PMID 20042613. doi:10.1074/jbc.M109.056960.
  6. ↑ Durand S, Angeletti S, Genti-Raimondi S (January 2004). "GTT1/StarD7, a novel phosphatidylcholine transfer protein-like highly expressed in gestational trophoblastic tumour: cloning and characterization". Placenta. 25 (1): 37–44. PMID 15013637. doi:10.1016/S0143-4004(03)00214-5.
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