STAMBP

STAMBP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSTAMBP, AMSH, MICCAP, STAM binding protein
External IDsMGI: 1917777 HomoloGene: 4719 GeneCards: STAMBP
Gene location (Human)
Chr.Chromosome 2 (human)[1]
BandNo data availableStart73,828,916 bp[1]
End73,873,659 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

10617

70527

Ensembl

ENSG00000124356

ENSMUSG00000006906

UniProt

O95630

Q9CQ26

RefSeq (mRNA)

NM_006463
NM_201647
NM_213622

NM_024239

RefSeq (protein)

NP_006454
NP_964010
NP_998787

NP_077201

Location (UCSC)Chr 2: 73.83 – 73.87 MbChr 2: 83.54 – 83.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

STAM-binding protein is a protein that in humans is encoded by the STAMBP gene.[5][6]

Function

Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.[6]

Mutations in this gene have been associated to cases of microcephaly (doi:10.1038/ng.2602)

Interactions

STAMBP has been shown to interact with RNF11,[7] Signal transducing adaptor molecule[5][8] and GRAP2.[9][10]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124356 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006906 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 Tanaka N, Kaneko K, Asao H, Kasai H, Endo Y, Fujita T, Takeshita T, Sugamura K (July 1999). "Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines". The Journal of Biological Chemistry. 274 (27): 19129–35. PMID 10383417. doi:10.1074/jbc.274.27.19129.
  6. 1 2 "Entrez Gene: STAMBP STAM binding protein".
  7. ↑ Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. PMID 14755250. doi:10.1038/sj.onc.1207319.
  8. ↑ Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. PMID 10982817. doi:10.1074/jbc.M007251200.
  9. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
  10. ↑ Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–90. PMC 2193052 Freely accessible. PMID 10224278. doi:10.1084/jem.189.9.1383.

Further reading

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