ST8SIA1

Identifiers

ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

External IDs

MGI: 106011 HomoloGene: 2282 GeneCards: ST8SIA1

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	No data available	Start	22,063,773 bp^[1]
Band	No data available	End	22,437,041 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	No data available	Start	142,821,545 bp^[2]
Band	No data available	End	142,964,452 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • sialyltransferase activity • transferase activity, transferring glycosyl groups • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
Cellular component	• integral component of membrane • Golgi membrane • Golgi apparatus • membrane
Biological process	• glycosphingolipid biosynthetic process • sialylation • protein glycosylation • cellular response to heat • positive regulation of cell proliferation • carbohydrate metabolic process • sphingolipid metabolic process • lipid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6489


20449

Ensembl


ENSG00000111728


ENSMUSG00000030283

UniProt


Q92185


Q64687

RefSeq (mRNA)


NM_001304450 NM_003034


NM_011374

RefSeq (protein)


NP_001291379 NP_003025


NP_035504

Location (UCSC)

Chr 12: 22.06 – 22.44 Mb

Chr 12: 142.82 – 142.96 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.^[5]^[6]

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.^[6]

In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111728 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030283 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M (Dec 1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J Biol Chem. 268 (30): 22782–7. PMID 7901202.
1 2 "Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1".
↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x.

Haraguchi M, Yamashiro S, Yamamoto A, et al. (1994). "Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10455–9. PMC 45039 . PMID 7937974. doi:10.1073/pnas.91.22.10455.
Nara K, Watanabe Y, Maruyama K, et al. (1994). "Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (17): 7952–6. PMC 44522 . PMID 8058740. doi:10.1073/pnas.91.17.7952.
Sasaki K, Kurata K, Kojima N, et al. (1994). "Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase).". J. Biol. Chem. 269 (22): 15950–6. PMID 8195250.
Nakayama J, Fukuda MN, Hirabayashi Y, et al. (1996). "Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme.". J. Biol. Chem. 271 (7): 3684–91. PMID 8631981. doi:10.1074/jbc.271.7.3684.
Matsuda Y, Nara K, Watanabe Y, et al. (1996). "Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse.". Genomics. 32 (1): 137–9. PMID 8786103. doi:10.1006/geno.1996.0090.
De Maria R, Lenti L, Malisan F, et al. (1997). "Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.". Science. 277 (5332): 1652–5. PMID 9287216. doi:10.1126/science.277.5332.1652.
Angata K, Suzuki M, McAuliffe J, et al. (2000). "Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.". J. Biol. Chem. 275 (24): 18594–601. PMID 10766765. doi:10.1074/jbc.M910204199.
Zeng G, Gao L, Suetake K, et al. (2002). "Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed.". Cancer Lett. 178 (1): 91–8. PMID 11849746. doi:10.1016/S0304-3835(01)00817-5.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Furukawa K, Horie M, Okutomi K, et al. (2003). "Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene.". Biochim. Biophys. Acta. 1627 (2-3): 71–8. PMID 12818424. doi:10.1016/s0167-4781(03)00076-9.
Moon SK, Kim HM, Lee YC, Kim CH (2004). "Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression.". J. Biol. Chem. 279 (32): 33063–70. PMID 15175338. doi:10.1074/jbc.M313462200.
Ha KT, Lee YC, Kim CH (2004). "Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2.". FEBS Lett. 568 (1-3): 183–7. PMID 15196944. doi:10.1016/j.febslet.2004.05.020.
Tomassini B, Malisan F, Franchi L, et al. (2005). "Calnexin suppresses GD3 synthase-induced apoptosis.". FASEB J. 18 (13): 1553–5. PMID 15319364. doi:10.1096/fj.04-1675fje.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Teintenier-Lelièvre M, Julien S, Juliant S, et al. (2006). "Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins.". Biochem. J. 392 (Pt 3): 665–74. PMC 1316308 . PMID 16120058. doi:10.1042/BJ20051120.
Kang NY, Kang Y, Kang SK, et al. (2006). "Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression.". Glycobiology. 16 (5): 375–89. PMID 16481330. doi:10.1093/glycob/cwj087.
Ko K, Furukawa K, Takahashi T, et al. (2006). "Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers.". Oncogene. 25 (52): 6924–35. PMID 16862187. doi:10.1038/sj.onc.1209683.
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities.". Med. Res. Rev. 37: 210–270. doi:10.1002/med.21407.

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ST8SIA1

References

Further reading