ST6GALNAC2

ST6GALNAC2

Identifiers

ST6GALNAC2, SAITL1, SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

External IDs

MGI: 107553 HomoloGene: 4714 GeneCards: ST6GALNAC2

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	76,565,379 bp^[1]
Band	No data available	End	76,586,956 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	116,675,303 bp^[2]
Band	No data available	End	116,694,868 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity, transferring glycosyl groups • transferase activity • alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity • sialyltransferase activity
Cellular component	• integral component of membrane • Golgi apparatus • membrane • Golgi membrane
Biological process	• sialylation • protein glycosylation • oligosaccharide metabolic process • O-glycan processing • protein N-linked glycosylation via asparagine
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


10610


20446


ENSG00000070731


ENSMUSG00000057286


Q9UJ37


P70277

RefSeq (mRNA)


NM_006456


NM_009180

RefSeq (protein)


NP_006447


NP_033206

Location (UCSC)

Chr 17: 76.57 – 76.59 Mb

Chr 17: 116.68 – 116.69 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070731 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057286 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sotiropoulou G, Kono M, Anisowicz A, Stenman G, Tsuji S, Sager R (May 2002). "Identification and functional characterization of a human GalNAc [alpha]2,6-sialyltransferase with altered expression in breast cancer". Mol Med. 8 (1): 42–55. PMC 2039932 . PMID 11984005.
↑ "Entrez Gene: ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2".

Further reading

Li GS, Zhu L, Zhang H, et al. (2007). "Variants of the ST6GALNAC2 promoter influence transcriptional activity and contribute to genetic susceptibility to IgA nephropathy.". Hum. Mutat. 28 (10): 950–7. PMID 17480010. doi:10.1002/humu.20543.
Raska M, Moldoveanu Z, Suzuki H, et al. (2007). "Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells.". J. Mol. Biol. 369 (1): 69–78. PMC 1995659 . PMID 17418236. doi:10.1016/j.jmb.2007.03.002.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. PMC 442148 . PMID 15231748. doi:10.1101/gr.2334104.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Samyn-Petit B, Krzewinski-Recchi MA, Steelant WF, et al. (2000). "Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells.". Biochim. Biophys. Acta. 1474 (2): 201–11. PMID 10742600. doi:10.1016/s0304-4165(00)00020-9.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.