SSX2IP

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1T2M, 1XZ9, 2AIN, 2EXG

Identifiers

Aliases

SSX2IP, ADIP, synovial sarcoma, X breakpoint 2 interacting protein, SSX family member 2 interacting protein, hMsd1

External IDs

MGI: 2139150 HomoloGene: 8522 GeneCards: SSX2IP

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	No data available	Start	84,643,707 bp^[1]
Band	No data available	End	84,690,803 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	No data available	Start	146,404,642 bp^[2]
Band	No data available	End	146,440,144 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• protein binding • protein domain specific binding
Cellular component	• cytoplasm • microtubule organizing center • adherens junction • cell junction • cell projection • cytoskeleton • cell leading edge • cell-cell adherens junction • nucleus • protein complex • ciliary basal body • centriolar satellite
Biological process	• regulation of cell motility • intraciliary transport involved in cilium assembly • regulation of Rac protein signal transduction • cell adhesion • cell projection organization • cilium morphogenesis • centrosome cycle
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


117178


99167

Ensembl


ENSG00000117155


ENSMUSG00000036825

UniProt


Q9Y2D8


Q8VC66

RefSeq (mRNA)


NM_001166293 NM_001166294 NM_001166295 NM_001166417 NM_014021


NM_001253768 NM_001253769 NM_001253770 NM_138744

RefSeq (protein)


NP_001159765 NP_001159766 NP_001159767 NP_001159889 NP_054740


NP_001240697 NP_001240698 NP_001240699 NP_620083

Location (UCSC)

Chr 1: 84.64 – 84.69 Mb

Chr 1: 146.4 – 146.44 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Afadin- and alpha-actinin-binding protein is a protein that in humans is encoded by the SSX2IP gene.^[5]

Interactions

SSX2IP has been shown to interact with MLLT4^[6] and Actinin, alpha 1.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117155 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036825 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: SSX2IP synovial sarcoma, X breakpoint 2 interacting protein".
1 2 Asada M, Irie K, Morimoto K, Yamada A, Ikeda W, Takeuchi M, Takai Y (February 2003). "ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions". The Journal of Biological Chemistry. 278 (6): 4103–11. PMID 12446711. doi:10.1074/jbc.M209832200.

Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. PMID 10231032. doi:10.1093/dnares/6.1.63.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. PMC 1083732 . PMID 11256614. doi:10.1093/embo-reports/kvd058.
de Bruijn DR, dos Santos NR, Kater-Baats E, Thijssen J, van den Berk L, Stap J, Balemans M, Schepens M, Merkx G, van Kessel AG (July 2002). "The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP". Genes, Chromosomes & Cancer. 34 (3): 285–98. PMID 12007189. doi:10.1002/gcc.10073.
Asada M, Irie K, Morimoto K, Yamada A, Ikeda W, Takeuchi M, Takai Y (February 2003). "ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions". The Journal of Biological Chemistry. 278 (6): 4103–11. PMID 12446711. doi:10.1074/jbc.M209832200.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, Wells JW, Banham AH, Mufti GJ (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications. 335 (4): 1293–304. PMID 16112646. doi:10.1016/j.bbrc.2005.08.024.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. PMC 1459365 . PMID 16565220. doi:10.1073/pnas.0507066103.

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SSX2IP

Interactions

References

Further reading