Relcovaptan

Relcovaptan
Clinical data

ATC code	none
Identifiers
IUPAC name 1-({(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-3-hydroxy-2,3-dihydro-1H-indol-2-yl}carbonyl)-L-prolinamide
Synonyms	(2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxyphenyl)sulfonyl-3-hydroxy-2H-indole-2-carbonyl]pyrrolidine-2-carboxamide
CAS Number	150375-75-0^Y
PubChem CID	60943
IUPHAR/BPS	2200
ChemSpider	54910^N
UNII	C1GL8G6G0O
ChEMBL	CHEMBL419667^N
Chemical and physical data
Formula	C₂₈H₂₇Cl₂N₃O₇S
Molar mass	620.501 g/mol
3D model (JSmol)	Interactive image
SMILES COC1=C(C=C(C=C1)S(=O)(=O)N2[C@H]([C@](C3=C2C=CC(=C3)Cl)(C4=CC=CC=C4Cl)O)C(=O)N5CCC[C@H]5C(=O)N)OC
InChI InChI=1S/C28H27Cl2N3O7S/c1-39-23-12-10-17(15-24(23)40-2)41(37,38)33-21-11-9-16(29)14-19(21)28(36,18-6-3-4-7-20(18)30)25(33)27(35)32-13-5-8-22(32)26(31)34/h3-4,6-7,9-12,14-15,22,25,36H,5,8,13H2,1-2H3,(H2,31,34)/t22-,25-,28+/m0/s1^N Key:CEBYCSRFKCEUSW-NAYZPBBASA-N^N
^NY (what is this?) (verify)

Relcovaptan (SR-49059) is a non-peptide vasopressin receptor antagonist, selective for the V1a subtype.^[1] It has shown positive initial results in tests against Raynaud's disease, dysmenorrhoea, and tocolysis,^[2] although it is not yet approved for clinical use.

References

↑ Lemmens-Gruber R, Kamyar M. Vasopressin antagonists. Cellular and Molecular Life Sciences. 2006 Aug;63(15):1766-79. PMID 16794787
↑ Decaux G, Soupart A, Vassart G. Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet. 2008 May 10;371(9624):1624-32. PMID 18468546

V_1A	Agonists: Felypressin Lypressin Ornipressin Selepressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Atosiban Conivaptan FR-218944 JNJ-17079166 JNJ-17308616 LY-307174 PF-184563 Relcovaptan RG7314 SRX246 SRX251 TC OT 39 WAY-267464 YM-218 YM-471 YM-35471
V_1B	Agonists: Desmopressin Felypressin Lypressin Ornipressin Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: ABT-436 ABT-558 Nelivaptan ORG-52186 (SCH-740935) TASP-0233278 TASP-0390325 TS-121 Ligands: TASP-699
V₂	Agonists: Desmopressin Felypressin Lypressin Ornipressin TC OT 39 Terlipressin Vasopressin (argipressin) Vasotocin (argiprestocin) Antagonists: Conivaptan JNJ-17079166 Lixivaptan Mozavaptan RWJ-351647 Satavaptan Tolvaptan YM-471 YM-35471
Unsorted	Antagonists: Ribuvaptan RWJ-339489 VMAX-367 VMAX-372 VMAX-382 YM-222546 Other inhibitors: Demeclocycline Lithium (lithium carbonate)

Others

See also: Receptor/signaling modulators; Signaling peptide/protein receptor modulators

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