Spondin 2

SPON2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3D34

Identifiers

Aliases

SPON2, DIL-1, DIL1, M-SPONDIN, MINDIN, spondin 2

External IDs

MGI: 1923724 HomoloGene: 40843 GeneCards: SPON2

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	No data available	Start	1,166,932 bp^[1]
Band	No data available	End	1,208,962 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	No data available	Start	33,198,184 bp^[2]
Band	No data available	End	33,218,455 bp^[2]

Gene ontology
Molecular function	• antigen binding • lipopolysaccharide binding • metal ion binding • protein binding
Cellular component	• proteinaceous extracellular matrix • extracellular region • extracellular exosome • extracellular space
Biological process	• mast cell mediated immunity • positive regulation of macrophage cytokine production • immune system process • defense response to fungus • axon guidance • response to lipopolysaccharide • cell adhesion • defense response to virus • defense response to bacterium • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • innate immune response • cellular response to lipopolysaccharide • opsonization • induction of bacterial agglutination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10417


100689

Ensembl


ENSG00000159674


ENSMUSG00000037379

UniProt


Q9BUD6


Q8BMS2

RefSeq (mRNA)


NM_012445 NM_001128325 NM_001199021


NM_133903

RefSeq (protein)


NP_001121797 NP_001185950 NP_036577


NP_598664

Location (UCSC)

Chr 4: 1.17 – 1.21 Mb

Chr 4: 33.2 – 33.22 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Spondin 2, also known as mindin, is a protein that in humans is encoded by the SPON2 gene.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159674 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037379 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Spondin 2, extracellular matrix protein".

Yan L, Wei X, Tang QZ, Feng J, Zhang Y, Liu C, Bian ZY, Zhang LF, Chen M, Bai X, Wang AB, Fassett J, Chen Y, He YW, Yang Q, Liu PP, Li H (October 2011). "Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling". Cardiovascular Research. 92 (1): 85–94. PMC 3657538 . PMID 21632881. doi:10.1093/cvr/cvr159.
Qian X, Li C, Pang B, Xue M, Wang J, Zhou J (2012). "Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker". PloS One. 7 (5): e37225. PMC 3352876 . PMID 22615945. doi:10.1371/journal.pone.0037225.
Feinstein Y, Klar A (June 2004). "The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities". The International Journal of Biochemistry & Cell Biology. 36 (6): 975–80. PMID 15094111. doi:10.1016/j.biocel.2004.01.002.
Li Y, Cao C, Jia W, Yu L, Mo M, Wang Q, Huang Y, Lim JM, Ishihara M, Wells L, Azadi P, Robinson H, He YW, Zhang L, Mariuzza RA (February 2009). "Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule". The EMBO Journal. 28 (3): 286–97. PMC 2637340 . PMID 19153605. doi:10.1038/emboj.2008.288.
Liao CH, Yeh SC, Huang YH, Chen RN, Tsai MM, Chen WJ, Chi HC, Tai PJ, Liao CJ, Wu SM, Cheng WL, Pai LM, Lin KH (March 2010). "Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion". Endocrine-Related Cancer. 17 (1): 99–111. PMID 19903741. doi:10.1677/ERC-09-0050.
Murakoshi M, Tanimoto M, Gohda T, Hagiwara S, Takagi M, Horikoshi S, Tomino Y (July 2011). "Mindin: a novel marker for podocyte injury in diabetic nephropathy". Nephrology, Dialysis, Transplantation. 26 (7): 2153–60. PMID 21098016. doi:10.1093/ndt/gfq708.
Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J (October 1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics. 61 (1): 5–14. PMID 10512675. doi:10.1006/geno.1999.5939.
Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP (March 2006). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics. 25 (1): 9–15. PMID 16368877. doi:10.1152/physiolgenomics.00121.2005.
Kong A, Thorleifsson G, Stefansson H, Masson G, Helgason A, Gudbjartsson DF, Jonsdottir GM, Gudjonsson SA, Sverrisson S, Thorlacius T, Jonasdottir A, Hardarson GA, Palsson ST, Frigge ML, Gulcher JR, Thorsteinsdottir U, Stefansson K (March 2008). "Sequence variants in the RNF212 gene associate with genome-wide recombination rate". Science. 319 (5868): 1398–401. PMID 18239089. doi:10.1126/science.1152422.

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Spondin 2

References

Further reading