SNW1

SNW1
Identifiers
Aliases	SNW1, Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP, SNW domain containing 1, SKIP1, FUN20
External IDs	MGI: 1913604 HomoloGene: 56557 GeneCards: SNW1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band No data available Start 77,717,599 bp[1] End 77,761,207 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band No data available Start 87,449,075 bp[2] End 87,472,274 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • transcription corepressor activity • transcription coactivator activity • nuclear hormone receptor binding • Notch binding • protein binding • retinoic acid receptor binding • SMAD binding • vitamin D receptor binding • RNA binding • enzyme binding • androgen receptor binding Cellular component • catalytic step 2 spliceosome • nuclear matrix • SMAD3-SMAD4 protein complex • nucleoplasm • cyclin/CDK positive transcription elongation factor complex • spliceosomal complex • nucleus • nuclear body • post-mRNA release spliceosomal complex • nuclear speck Biological process • Notch signaling pathway • cellular response to retinoic acid • positive regulation of transforming growth factor beta receptor signaling pathway • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • regulation of transcription, DNA-templated • positive regulation of mRNA splicing, via spliceosome • regulation of retinoic acid receptor signaling pathway • regulation of transcription from RNA polymerase II promoter • mRNA processing • regulation of vitamin D receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter • positive regulation of neurogenesis • retinoic acid receptor signaling pathway • positive regulation of histone H3-K4 methylation • RNA splicing • positive regulation of vitamin D receptor signaling pathway • transcription initiation from RNA polymerase II promoter • viral process • negative regulation of transcription, DNA-templated • positive regulation by host of viral transcription • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • mRNA splicing, via spliceosome • generation of catalytic spliceosome for second transesterification step Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	22938	66354
Ensembl	ENSG00000100603	ENSMUSG00000021039
UniProt	Q13573	Q9CSN1
RefSeq (mRNA)	NM_012245 NM_001318844	NM_025507
RefSeq (protein)	NP_001305773 NP_036377	NP_079783
Location (UCSC)	Chr 14: 77.72 – 77.76 Mb	Chr 14: 87.45 – 87.47 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.^[5][6][7]

Function

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.^[7]

Interactions

SNW1 has been shown to interact with:

References

Further reading