SNRPB2
U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.[5][6]
The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000125870 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008333 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Habets WJ, Sillekens PT, Hoet MH, Schalken JA, Roebroek AJ, Leunissen JA, van de Ven WJ, van Venrooij WJ (May 1987). "Analysis of a cDNA clone expressing a human autoimmune antigen: full-length sequence of the U2 small nuclear RNA-associated B" antigen". Proc Natl Acad Sci U S A. 84 (8): 2421–5. PMC 304663
. PMID 2951739. doi:10.1073/pnas.84.8.2421. - 1 2 "Entrez Gene: SNRPB2 small nuclear ribonucleoprotein polypeptide B".
Further reading
- Feeney RJ, Zieve GW (1990). "Nuclear exchange of the U1 and U2 snRNP-specific proteins.". J. Cell Biol. 110 (4): 871–81. PMC 2116108 . PMID 2139037. doi:10.1083/jcb.110.4.871.
- Laitinen J, Saris P, Hölttä E, Pettersson I (1995). "U2-snRNP B" protein gene is an early growth-inducible gene.". J. Cell. Biochem. 58 (4): 490–8. PMID 7593271. doi:10.1002/jcb.240580412.
- Hong W, Bennett M, Xiao Y, et al. (1997). "Association of U2 snRNP with the spliceosomal complex E.". Nucleic Acids Res. 25 (2): 354–61. PMC 146436 . PMID 9016565. doi:10.1093/nar/25.2.354.
- Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell. 90 (6): 1013–21. PMID 9323129. doi:10.1016/S0092-8674(00)80367-0.
- Moraitou M, Patrinou-Georgoula M, Guialis A (1998). "Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles.". Biochem. J. 332 (1): 135–44. PMC 1219461 . PMID 9576861.
- Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA.". Nature. 394 (6694): 645–50. PMID 9716128. doi:10.1038/29234.
- Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. PMID 9731529. doi:10.1038/1700.
- Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.". Hum. Mol. Genet. 8 (13): 2351–7. PMID 10556282. doi:10.1093/hmg/8.13.2351.
- Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II.". J. Cell Biol. 152 (1): 75–85. PMC 2193649 . PMID 11149922. doi:10.1083/jcb.152.1.75.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature. 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a.
- Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation.". Nature. 414 (6866): 929–33. PMID 11780068. doi:10.1038/414929a.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA. 8 (4): 426–39. PMC 1370266 . PMID 11991638. doi:10.1017/S1355838202021088.
- Chung S, Zhou Z, Huddleston KA, et al. (2002). "Crooked neck is a component of the human spliceosome and implicated in the splicing process.". Biochim. Biophys. Acta. 1576 (3): 287–97. PMID 12084575. doi:10.1016/S0167-4781(02)00368-8.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. PMID 15592455. doi:10.1038/nbt1046.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.
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