SNRPA1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1A9N

Identifiers

Aliases

SNRPA1, Lea1, small nuclear ribonucleoprotein polypeptide A'

External IDs

MGI: 1916231 HomoloGene: 2325 GeneCards: SNRPA1

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	No data available	Start	101,281,510 bp^[1]
Band	No data available	End	101,295,282 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	No data available	Start	66,059,003 bp^[2]
Band	No data available	End	66,074,587 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• U2 snRNA binding • protein binding • RNA binding
Cellular component	• catalytic step 2 spliceosome • spliceosomal complex • intracellular ribonucleoprotein complex • small nuclear ribonucleoprotein complex • nucleus • U2 snRNP • nucleoplasm • nuclear speck • viral nucleocapsid
Biological process	• mRNA splicing, via spliceosome • mRNA processing • RNA splicing • interleukin-12-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6627


68981

Ensembl


ENSG00000131876


ENSMUSG00000030512

UniProt


P09661


P57784

RefSeq (mRNA)


NM_003090


NM_021336

RefSeq (protein)


NP_003081


NP_067311

Location (UCSC)

Chr 15: 101.28 – 101.3 Mb

Chr 15: 66.06 – 66.07 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.^[5]^[6]

Interactions

SNRPA1 has been shown to interact with CDC5L.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000131876 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030512 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Sillekens PT; Beijer RP; Habets WJ; van Verooij WJ (May 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Res. 17 (5): 1893–906. PMC 317531 . PMID 2928112. doi:10.1093/nar/17.5.1893.
↑ "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
↑ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. ENGLAND. 19 (23): 6569–81. ISSN 0261-4189. PMC 305846 . PMID 11101529. doi:10.1093/emboj/19.23.6569.

Ohno M; Kataoka N; Shimura Y (1991). "A nuclear cap binding protein from HeLa cells.". Nucleic Acids Res. 18 (23): 6989–95. PMC 332760 . PMID 2148205. doi:10.1093/nar/18.23.6989.
Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
Kjems J; Sharp PA (1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". J. Virol. 67 (8): 4769–76. PMC 237863 . PMID 8331728.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Blencowe BJ; Issner R; Nickerson JA; Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. PMC 316672 . PMID 9531537. doi:10.1101/gad.12.7.996.
Price SR; Evans PR; Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature. 394 (6694): 645–50. PMID 9716128. doi:10.1038/29234.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. PMID 9731529. doi:10.1038/1700.
Eldridge AG; Li Y; Sharp PA; Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. PMC 26846 . PMID 10339552. doi:10.1073/pnas.96.11.6125.
Lundin M; Mikkelsen B; Gudim M; Syed M (2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine biotechnology. 2 (2): 204–211. PMID 10811961. doi:10.1007/s101269900015.
Fong YW; Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. PMID 11780068. doi:10.1038/414929a.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. PMID 11790298. doi:10.1016/S0960-9822(01)00650-9.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. PMC 1370266 . PMID 11991638. doi:10.1017/S1355838202021088.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. PMID 15635413. doi:10.1038/nature03207.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. PMID 16964243. doi:10.1038/nbt1240.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948 . PMID 17353931. doi:10.1038/msb4100134.

RNA-binding protein: Ribonucleoproteins
snRNP	A A1 B B2 C D1 D2 D3 E F G N 70K/U1 spliceosomal RNA SNRNP200
hnRNP	A0 C L R
Other transcription	Telomerase
Translation	Ribosome
Vault ribonucleoprotein particles	Major vault protein
Other	Signal recognition particle

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SNRPA1

Interactions

References

Further reading