SNAP91

Identifiers

SNAP91, AP180, CALM, synaptosome associated protein 91kDa, synaptosome associated protein 91

External IDs

MGI: 109132 HomoloGene: 8429 GeneCards: SNAP91

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	No data available	Start	83,552,880 bp^[1]
Band	No data available	End	83,709,691 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	No data available	Start	86,765,923 bp^[2]
Band	No data available	End	86,880,654 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• clathrin binding • 1-phosphatidylinositol binding • protein binding • phospholipid binding • protein kinase binding
Cellular component	• plasma membrane • clathrin-coated pit • membrane • clathrin-coated vesicle
Biological process	• clathrin coat assembly • protein transport • regulation of clathrin-dependent endocytosis • transport • chemical synaptic transmission
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9892


20616

Ensembl


ENSG00000065609


ENSMUSG00000033419

UniProt


O60641


Q61548

RefSeq (mRNA)

NM_001242792 NM_001242793 NM_001242794 NM_001256717 NM_001256718
NM_014841


NM_001277982 NM_001277983 NM_001277985 NM_001277986 NM_013669

RefSeq (protein)

NP_001229721 NP_001229722 NP_001229723 NP_001243646 NP_001243647
NP_055656


NP_001264911 NP_001264912 NP_001264914 NP_001264915 NP_038697

Location (UCSC)

Chr 6: 83.55 – 83.71 Mb

Chr 6: 86.77 – 86.88 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Clathrin coat assembly protein AP180 is a protein that in humans is encoded by the SNAP91 gene.^[5]^[6]^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000065609 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033419 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. PMID 9734811. doi:10.1093/dnares/5.3.169.
↑ Yao PJ, O'Herron TM, Coleman PD (Dec 2002). "Immunohistochemical characterization of clathrin assembly protein AP180 and synaptophysin in human brain". Neurobiology of Aging. 24 (1): 173–8. PMID 12493563. doi:10.1016/S0197-4580(02)00055-6.
↑ Tebar F, Bohlander SK, Sorkin A (August 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Molecular Biology of the Cell. 10 (8): 2687–702. PMC 25500 . PMID 10436022. doi:10.1091/mbc.10.8.2687.
↑ "Entrez Gene: SNAP91 synaptosomal-associated protein, 91kDa homolog (mouse)".

Murphy JE, Hanover JA, Froehlich M, DuBois G, Keen JH (August 1994). "Clathrin assembly protein AP-3 is phosphorylated and glycosylated on the 50-kDa structural domain". The Journal of Biological Chemistry. 269 (33): 21346–52. PMID 8063760.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. PMID 8619474. doi:10.1006/abio.1996.0138.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. PMC 139146 . PMID 9110174. doi:10.1101/gr.7.4.353.
Traub LM, Downs MA, Westrich JL, Fremont DH (August 1999). "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly". Proceedings of the National Academy of Sciences of the United States of America. 96 (16): 8907–12. PMC 17706 . PMID 10430869. doi:10.1073/pnas.96.16.8907.
Yao PJ, Morsch R, Callahan LM, Coleman PD (1999). "Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry". Neuroscience. 94 (2): 389–94. PMID 10579202. doi:10.1016/S0306-4522(99)00360-7.
Slepnev VI, Ochoa GC, Butler MH, De Camilli P (June 2000). "Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites". The Journal of Biological Chemistry. 275 (23): 17583–9. PMID 10748223. doi:10.1074/jbc.M910430199.
Han SJ, Lee JH, Hong SH, Park SD, Kim CG, Song MD, Park TK, Kim CG (January 2002). "AP180 binds to the C-terminal SH2 domain of phospholipase C-gamma1 and inhibits its enzymatic activity". Biochemical and Biophysical Research Communications. 290 (1): 35–41. PMID 11779129. doi:10.1006/bbrc.2001.6154.
Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (July 2003). "Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin". The Journal of Biological Chemistry. 278 (28): 25357–68. PMID 12732633. doi:10.1074/jbc.M303738200.
Hussain NK, Yamabhai M, Bhakar AL, Metzler M, Ferguson SS, Hayden MR, McPherson PS, Kay BK (August 2003). "A role for epsin N-terminal homology/AP180 N-terminal homology (ENTH/ANTH) domains in tubulin binding". The Journal of Biological Chemistry. 278 (31): 28823–30. PMID 12750376. doi:10.1074/jbc.M300995200.
Morgan JR, Prasad K, Jin S, Augustine GJ, Lafer EM (August 2003). "Eps15 homology domain-NPF motif interactions regulate clathrin coat assembly during synaptic vesicle recycling". The Journal of Biological Chemistry. 278 (35): 33583–92. PMID 12807910. doi:10.1074/jbc.M304346200.
Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V (July 2003). "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma". The Journal of Cell Biology. 162 (1): 113–24. PMC 2172713 . PMID 12847086. doi:10.1083/jcb.200301006.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (November 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. PMID 15345747. doi:10.1074/mcp.M400085-MCP200.
Zhan X, Desiderio DM (December 2004). "The human pituitary nitroproteome: detection of nitrotyrosyl-proteins with two-dimensional Western blotting, and amino acid sequence determination with mass spectrometry". Biochemical and Biophysical Research Communications. 325 (4): 1180–6. PMID 15555551. doi:10.1016/j.bbrc.2004.10.169.

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SNAP91

References

Further reading