SLK (gene)

SLK

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2J51, 2JFL, 2JFM, 2UV2, 4USF

Identifiers

Aliases

SLK, LOSK, STK2, bA16H23.1, se20-9, STE20 like kinase

External IDs

MGI: 103241 HomoloGene: 22515 GeneCards: SLK

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	No data available	Start	103,967,201 bp^[1]
Band	No data available	End	104,029,233 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	No data available	Start	47,579,678 bp^[2]
Band	No data available	End	47,645,246 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• transferase activity • nucleotide binding • protein kinase activity • protein homodimerization activity • kinase activity • protein serine/threonine kinase activity • protein binding • identical protein binding • ATP binding • cadherin binding
Cellular component	• extracellular exosome • cell leading edge • perinuclear region of cytoplasm • cytoplasm
Biological process	• phosphorylation • protein phosphorylation • cytoplasmic microtubule organization • regulation of focal adhesion assembly • protein autophosphorylation • apoptotic process • regulation of cell migration • regulation of apoptotic process • regulation of mitotic cell cycle • signal transduction by protein phosphorylation • stress-activated protein kinase signaling cascade • activation of protein kinase activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9748


20874

Ensembl


ENSG00000065613


ENSMUSG00000025060

UniProt


Q9H2G2


O54988

RefSeq (mRNA)


NM_001304743 NM_014720


NM_001164639 NM_009289

RefSeq (protein)


NP_001291672 NP_055535


NP_001158111 NP_033315

Location (UCSC)

Chr 10: 103.97 – 104.03 Mb

Chr 10: 47.58 – 47.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.^[5]^[6]

Interactions

SLK (gene) has been shown to interact with PDZK1.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000065613 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025060 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science. 233 (4769): 1175–80. PMID 3526554. doi:10.1126/science.3526554.
↑ "Entrez Gene: SLK STE20-like kinase (yeast)".
↑ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. PMID 14531806. doi:10.1046/j.1523-1755.2003.00266.x.

Yan Y, Nguyen H, Dalmasso G, Sitaraman SV, Merlin D (Feb 2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochimica et Biophysica Acta. 1769 (2): 106–16. PMC 1865517 . PMID 17321610. doi:10.1016/j.bbaexp.2007.01.003.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. PMID 17081983. doi:10.1016/j.cell.2006.09.026.
Chaar Z, O'reilly P, Gelman I, Sabourin LA (Sep 2006). "v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II". The Journal of Biological Chemistry. 281 (38): 28193–9. PMID 16837460. doi:10.1074/jbc.M605665200.
Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. PMID 14531806. doi:10.1046/j.1523-1755.2003.00266.x.
Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. PMC 187542 . PMID 12421765. doi:10.1101/gr.406902.
Dan I, Watanabe NM, Kusumi A (May 2001). "The Ste20 group kinases as regulators of MAP kinase cascades". Trends in Cell Biology. 11 (5): 220–30. PMID 11316611. doi:10.1016/S0962-8924(01)01980-8.
Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D (Jan 2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 629–34. PMC 14639 . PMID 11149944. doi:10.1073/pnas.021386498.
Yamada E, Tsujikawa K, Itoh S, Kameda Y, Kohama Y, Yamamoto H (Feb 2000). "Molecular cloning and characterization of a novel human STE20-like kinase, hSLK". Biochimica et Biophysica Acta. 1495 (3): 250–62. PMID 10699464. doi:10.1016/S0167-4889(99)00164-0.
Sabourin LA, Tamai K, Seale P, Wagner J, Rudnicki MA (Jan 2000). "Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region". Molecular and Cellular Biology. 20 (2): 684–96. PMC 85169 . PMID 10611247. doi:10.1128/MCB.20.2.684-696.2000.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. PMID 9039502. doi:10.1093/dnares/3.5.321.

PDB gallery

2j51: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 5-AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE

2jfl: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (DIPHOSPHORYLATED FORM) BOUND TO 5- AMINO-3-((4-(AMINOSULFONYL)PHENYL)AMINO)-N-(2,6- DIFLUOROPHENYL)-1H-1,2, 4-TRIAZOLE-1-CARBOTHIOAMIDE

2jfm: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE (UNLIGANDED FORM)

2uv2: CRYSTAL STRUCTURE OF HUMAN STE20-LIKE KINASE BOUND TO 4-(4-(5-CYCLOPROPYL-1H-PYRAZOL-3-YLAMINO)-QUINAZOLIN-2-YLAMINO)-PHENYL)-ACETONITRILE

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SLK (gene)

Interactions

References

Further reading