SHC3

Identifiers

SHC3, N-Shc, NSHC, RAI, SHCC, SHC adaptor protein 3

External IDs

MGI: 106179 HomoloGene: 7536 GeneCards: SHC3

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	No data available	Start	89,005,771 bp^[1]
Band	No data available	End	89,178,767 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	No data available	Start	51,431,041 bp^[2]
Band	No data available	End	51,569,419 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• receptor tyrosine kinase binding • signal transducer activity • protein binding • Ras guanyl-nucleotide exchange factor activity • phosphotyrosine residue binding
Cellular component	• cytosol • plasma membrane
Biological process	• intracellular signal transduction • epidermal growth factor receptor signaling pathway • synaptic transmission, glutamatergic • transmembrane receptor protein tyrosine kinase signaling pathway • MAPK cascade • central nervous system development • learning or memory • Ras protein signal transduction • signal transduction • positive regulation of GTPase activity • axon guidance
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


53358


20418

Ensembl


ENSG00000148082


ENSMUSG00000021448

UniProt


Q92529


Q61120

RefSeq (mRNA)


NM_016848


NM_009167

RefSeq (protein)


NP_058544


NP_033193

Location (UCSC)

Chr 9: 89.01 – 89.18 Mb

Chr 9: 51.43 – 51.57 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.^[5]^[6]

Interactions

SHC3 has been shown to interact with RICS^[7] and TrkB.^[8]^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148082 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021448 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nakamura T; Sanokawa R; Sasaki Y; Ayusawa D; Oishi M; Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.
↑ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
↑ Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. United States. 22 (24): 8721–34. ISSN 0270-7306. PMC 139861 . PMID 12446789. doi:10.1128/MCB.22.24.8721-8734.2002.
↑ Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. UNITED STATES. 273 (12): 6960–7. ISSN 0021-9258. PMID 9507002. doi:10.1074/jbc.273.12.6960.
↑ Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. United States. 294 (5): 1087–92. ISSN 0006-291X. PMID 12074588. doi:10.1016/S0006-291X(02)00606-X.

O'Bryan JP, Songyang Z, Cantley L, et al. (1996). "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain.". Proc. Natl. Acad. Sci. U.S.A. 93 (7): 2729–34. PMC 39699 . PMID 8610109. doi:10.1073/pnas.93.7.2729.
Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.". Oncogene. 13 (3): 633–41. PMID 8760305.
Menegon A; Leoni C; Benfenati F; Valtorta F (1997). "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.". Biochem. Biophys. Res. Commun. 238 (3): 800–5. PMID 9325171. doi:10.1006/bbrc.1997.7393.
Wang JF, Ganju RK, Liu ZY, et al. (1997). "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor.". Blood. 90 (9): 3507–15. PMID 9345034.
Nakamura T; Muraoka S; Sanokawa R; Mori N (1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.". J. Biol. Chem. 273 (12): 6960–7. PMID 9507002. doi:10.1074/jbc.273.12.6960.
Cook KK; Fadool DA (2002). "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase.". J. Biol. Chem. 277 (15): 13268–80. PMC 2779217 . PMID 11812778. doi:10.1074/jbc.M108898200.
Tarr PE, Roncarati R, Pelicci G, et al. (2002). "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.". J. Biol. Chem. 277 (19): 16798–804. PMID 11877420. doi:10.1074/jbc.M110286200.
Liu HY; Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.". J. Biol. Chem. 277 (29): 26046–56. PMID 12006576. doi:10.1074/jbc.M111659200.
Miyake I, Hakomori Y, Shinohara A, et al. (2002). "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines.". Oncogene. 21 (38): 5823–34. PMID 12185581. doi:10.1038/sj.onc.1205735.
Pelicci G, Troglio F, Bodini A, et al. (2002). "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.". Mol. Cell. Biol. 22 (20): 7351–63. PMC 139827 . PMID 12242309. doi:10.1128/MCB.22.20.7351-7363.2002.
Nakamura T, Komiya M, Sone K, et al. (2003). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.". Mol. Cell. Biol. 22 (24): 8721–34. PMC 139861 . PMID 12446789. doi:10.1128/MCB.22.24.8721-8734.2002.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Miyake I, Hakomori Y, Misu Y, et al. (2005). "Domain-specific function of ShcC docking protein in neuroblastoma cells.". Oncogene. 24 (19): 3206–15. PMID 15735675. doi:10.1038/sj.onc.1208523.
Magrassi L, Conti L, Lanterna A, et al. (2005). "Shc3 affects human high-grade astrocytomas survival.". Oncogene. 24 (33): 5198–206. PMID 15870690. doi:10.1038/sj.onc.1208708.
De Falco V, Guarino V, Malorni L, et al. (2005). "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors.". Oncogene. 24 (41): 6303–13. PMID 15940252. doi:10.1038/sj.onc.1208776.
Toschi E, Bacigalupo I, Strippoli R, et al. (2006). "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway.". Mol. Biol. Cell. 17 (4): 1985–94. PMC 1415297 . PMID 16436505. doi:10.1091/mbc.E05-08-0717.
Li MD, Sun D, Lou XY, et al. (2007). "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence.". Mol. Psychiatry. 12 (5): 462–73. PMID 17179996. doi:10.1038/sj.mp.4001933.

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SHC3

Interactions

References

Further reading