SETD5

SETD5
Identifiers
AliasesSETD5, SET domain containing 5
External IDsMGI: 1920145 HomoloGene: 12485 GeneCards: SETD5
Gene location (Human)
Chr.Chromosome 3 (human)[1]
BandNo data availableStart9,397,615 bp[1]
End9,479,240 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

55209

72895

Ensembl

ENSG00000168137

ENSMUSG00000034269

UniProt

Q9C0A6

Q5XJV7

RefSeq (mRNA)

NM_001080517
NM_001292043
NM_018187
NM_001349451

NM_028385
NM_173005

RefSeq (protein)

NP_001073986
NP_001278972
NP_001336380

NP_082661
NP_766593

Location (UCSC)Chr 3: 9.4 – 9.48 MbChr 3: 113.08 – 113.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SET domain containing 5 is a protein that in humans is encoded by the SETD5 gene. [5]

Model organisms

Model organisms have been used in the study of SETD5 function. A conditional knockout mouse line called Setd5tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletion.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000168137 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034269 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ "Entrez Gene: SET domain containing 5". Retrieved 2013-10-07.
  6. ↑ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  7. 1 2 "International Mouse Phenotyping Consortium".
  8. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. PMC 3572410 Freely accessible. PMID 21677750. doi:10.1038/nature10163.
  9. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a.
  10. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018.
  11. ↑ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. PMC 3717207 Freely accessible. PMID 23870131. doi:10.1016/j.cell.2013.06.022.
  12. 1 2 "Infection and Immunity Immunophenotyping (3i) Consortium".


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