SEPT10

SEPT10
Identifiers
AliasesSEPT10, septin 10
External IDsMGI: 1918110 HomoloGene: 27035 GeneCards: SEPT10
Gene location (Human)
Chr.Chromosome 2 (human)[1]
BandNo data availableStart109,542,982 bp[1]
End109,614,206 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

151011

103080

Ensembl

ENSG00000186522

ENSMUSG00000019917

UniProt

Q9P0V9

Q8C650

RefSeq (mRNA)

NM_001024910
NM_001024911

RefSeq (protein)

NP_001020081
NP_001020082

Location (UCSC)Chr 2: 109.54 – 109.61 MbChr 2: 59.14 – 59.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.[5]

Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186522 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019917 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. 1 2 "Entrez Gene: Septin 10".

Further reading

  • Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (May 2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications. 304 (2): 393–8. PMID 12711328. doi:10.1016/s0006-291x(03)00601-6. 
  • Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (January 2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia. 22 (1): 224–6. PMID 17657217. doi:10.1038/sj.leu.2404867. 
  • Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (April 2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science. 103 (4): 821–7. PMID 22320903. doi:10.1111/j.1349-7006.2012.02221.x. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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