SEPT1

SEPT1
Identifiers
AliasesSEPT1, DIFF6, LARP, PNUTL3, SEP1, septin 1
External IDsMGI: 1858916 HomoloGene: 23009 GeneCards: SEPT1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
BandNo data availableStart30,378,133 bp[1]
End30,395,991 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1731

54204

Ensembl

ENSG00000180096

ENSMUSG00000000486

UniProt

Q8WYJ6

P42209

RefSeq (mRNA)

NM_052838

NM_017461

RefSeq (protein)

NP_443070

NP_059489

Location (UCSC)Chr 16: 30.38 – 30.4 MbChr 16: 127.21 – 127.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin-1 is a protein that in humans is encoded by the SEPT1 gene.[5][6]

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000180096 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000486 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. PMID 8697812. doi:10.1159/000134343.
  6. 1 2 "Entrez Gene: SEPT1 septin 1".

Further reading

  • Nottenburg C, Gallatin WM, St John T (November 1990). "Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences". Gene. 95 (2): 279–84. PMID 2174398. doi:10.1016/0378-1119(90)90372-X. 
  • Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (November 1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease". The American Journal of Pathology. 153 (5): 1551–60. PMC 1853406 Freely accessible. PMID 9811347. doi:10.1016/S0002-9440(10)65743-4. 
  • Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765. 
  • Qi M, Yu W, Liu S, Jia H, Tang L, Shen M, Yan X, Saiyin H, Lang Q, Wan B, Zhao S, Yu L (October 2005). "Septin1, a new interaction partner for human serine/threonine kinase aurora-B". Biochemical and Biophysical Research Communications. 336 (3): 994–1000. PMID 16179162. doi:10.1016/j.bbrc.2005.06.212. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209. 
  • Kato Y, Uzawa K, Yamamoto N, Kouzu Y, Koike H, Shiiba M, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (November 2007). "Overexpression of Septin1: possible contribution to the development of oral cancer". International Journal of Oncology. 31 (5): 1021–8. PMID 17912427. doi:10.3892/ijo.31.5.1021. 
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