SEMA5A
Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[5][6][7]
Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][7]
Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000112902 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022231 - Ensembl, May 2017
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. PMID 8817451. doi:10.1016/0925-4773(96)00525-4.
- ↑ Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. PMID 9464278. doi:10.1006/bbrc.1997.8027.
- 1 2 "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
- Simmons AD, Overhauser J, Lovett M (1997). "Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library.". Genome Res. 7 (2): 118–27. PMID 9049630. doi:10.1101/gr.7.2.118.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241
. PMID 12477932. doi:10.1073/pnas.242603899. - Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
- Artigiani S, Conrotto P, Fazzari P, et al. (2005). "Plexin-B3 is a functional receptor for semaphorin 5A.". EMBO Rep. 5 (7): 710–4. PMC 1299100 . PMID 15218527. doi:10.1038/sj.embor.7400189.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. PMC 514446 . PMID 15302935. doi:10.1073/pnas.0404720101.
- Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature. 431 (7006): 268–74. PMID 15372022. doi:10.1038/nature02919.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. PMC 1356129 . PMID 16344560. doi:10.1101/gr.4039406.
- Melin M, Carlsson B, Anckarsater H, et al. (2007). "Constitutional downregulation of SEMA5A expression in autism.". Neuropsychobiology. 54 (1): 64–9. PMC 2553518 . PMID 17028446. doi:10.1159/000096040.
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