SECISBP2

Identifiers

SECISBP2, SBP2, SECIS binding protein 2

External IDs

MGI: 1922670 HomoloGene: 11415 GeneCards: SECISBP2

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	No data available	Start	89,318,506 bp^[1]
Band	No data available	End	89,359,662 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	No data available	Start	51,651,697 bp^[2]
Band	No data available	End	51,684,044 bp^[2]

RNA expression pattern

More reference expression data

Gene ontology
Molecular function	• mRNA 3'-UTR binding • protein binding • RNA binding • selenocysteine insertion sequence binding • ribonucleoprotein complex binding
Cellular component	• nucleus • mitochondrion • intracellular ribonucleoprotein complex
Biological process	• translation • striatum development • neuron development • negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • selenocysteine incorporation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


79048


75420

Ensembl


ENSG00000187742


ENSMUSG00000035139

UniProt


Q96T21


n/a

RefSeq (mRNA)


NM_001282688 NM_001282689 NM_001282690 NM_024077


NM_029279 NM_001308448

RefSeq (protein)


NP_001269617 NP_001269618 NP_001269619 NP_076982


n/a

Location (UCSC)

Chr 9: 89.32 – 89.36 Mb

Chr 9: 51.65 – 51.68 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

SECIS-binding protein 2 (commonly referred to as SBP2) is a protein that in humans is encoded by the SECISBP2 gene.^[5]^[6]

Function

The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. SBP2 is a nuclear protein that functions as a SECIS binding protein, but experimental evidence indicates that SBP2 is cytoplasmic.^[6]

Clinical significance

Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187742 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035139 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. PMC 311072 . PMID 11230166. doi:10.1101/gr.GR1547R.
1 2 3 "Entrez Gene: SECISBP2 SECIS binding protein 2".

Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791.
Copeland PR, Fletcher JE, Carlson BA, Hatfield DL, Driscoll DM (January 2000). "A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs". The EMBO Journal. 19 (2): 306–14. PMC 305564 . PMID 10637234. doi:10.1093/emboj/19.2.306.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. PMC 310948 . PMID 11076863. doi:10.1101/gr.143000.
Low SC, Grundner-Culemann E, Harney JW, Berry MJ (December 2000). "SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy". The EMBO Journal. 19 (24): 6882–90. PMC 305907 . PMID 11118223. doi:10.1093/emboj/19.24.6882.
Lescure A, Allmang C, Yamada K, Carbon P, Krol A (May 2002). "cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2". Gene. 291 (1-2): 279–85. PMID 12095701. doi:10.1016/S0378-1119(02)00629-7.
Allmang C, Carbon P, Krol A (October 2002). "The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding". Rna. 8 (10): 1308–18. PMC 1370339 . PMID 12403468. doi:10.1017/S1355838202020034.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. PMC 528930 . PMID 15489336. doi:10.1101/gr.2576704.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. PMID 16189514. doi:10.1038/nature04209.
Dumitrescu AM, Liao XH, Abdullah MS, Lado-Abeal J, Majed FA, Moeller LC, Boran G, Schomburg L, Weiss RE, Refetoff S (November 2005). "Mutations in SECISBP2 result in abnormal thyroid hormone metabolism". Nature Genetics. 37 (11): 1247–52. PMID 16228000. doi:10.1038/ng1654.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. PMC 1347501 . PMID 16381901. doi:10.1093/nar/gkj139.
Papp LV, Lu J, Striebel F, Kennedy D, Holmgren A, Khanna KK (July 2006). "The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function". Molecular and Cellular Biology. 26 (13): 4895–910. PMC 1489162 . PMID 16782878. doi:10.1128/MCB.02284-05.

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SECISBP2

Function

Clinical significance

See also

References

Further reading