Secretagogin

SCGN
Identifiers
AliasesSCGN, CALBL, DJ501N12.8, SECRET, SEGN, setagin, secretagogin, EF-hand calcium binding protein
External IDsMGI: 2384873 HomoloGene: 5088 GeneCards: SCGN
Gene location (Human)
Chr.Chromosome 6 (human)[1]
BandNo data availableStart25,652,201 bp[1]
End25,701,783 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10590

214189

Ensembl

ENSG00000079689

ENSMUSG00000021337

UniProt

O76038

Q91WD9

RefSeq (mRNA)

NM_006998

NM_145399

RefSeq (protein)

NP_008929

NP_663374

Location (UCSC)Chr 6: 25.65 – 25.7 MbChr 6: 23.95 – 23.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secretagogin is a protein that in humans is encoded by the SCGN gene.[5][6]

Function

The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in potassium chloride-stimulated calcium flux and cell proliferation.[6] This protein plays an important role in the release of the stress hormone Corticotropin-releasing hormone (CRH) and which only then enables stress processes in the brain.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000079689 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021337 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:".
  4. ↑ "Mouse PubMed Reference:".
  5. ↑ Wagner L; Oliyarnyk O; Gartner W; Nowotny P; Groeger M; Kaserer K; Waldhausl W; Pasternack MS (Sep 2000). "Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein". J Biol Chem. 275 (32): 24740–51. PMID 10811645. doi:10.1074/jbc.M001974200.
  6. 1 2 "Entrez Gene: SCGN secretagogin, EF-hand calcium binding protein".

Further reading

  • Gartner W, Lang W, Leutmetzer F, et al. (2002). "Cerebral expression and serum detectability of secretagogin, a recently cloned EF-hand Ca(2+)-binding protein.". Cereb. Cortex. 11 (12): 1161–9. PMID 11709487. doi:10.1093/cercor/11.12.1161. 
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature. 425 (6960): 805–11. PMID 14574404. doi:10.1038/nature02055. 
  • Zhan X; Evans CO; Oyesiku NM; Desiderio DM (2004). "Proteomics and transcriptomics analyses of secretagogin down-regulation in human non-functional pituitary adenomas.". Pituitary. 6 (4): 189–202. PMID 15237930. doi:10.1023/B:PITU.0000023426.99808.40. 
  • Zierhut B, Daneva T, Gartner W, et al. (2005). "Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene.". Biochem. Biophys. Res. Commun. 329 (4): 1193–9. PMID 15766553. doi:10.1016/j.bbrc.2005.02.093. 
  • Skovhus KV, Bergholdt R, Erichsen C, et al. (2007). "Identification and characterization of secretagogin promoter activity.". Scand. J. Immunol. 64 (6): 639–45. PMID 17083620. doi:10.1111/j.1365-3083.2006.01854.x. 
  • Romanov R.; Alpar A.; et al. (2014). "A secretagogin locus of the mammalian hypothalamus controls stress hormone release.". EMBO Journal. 34: 36–54. doi:10.15252/embj.201488977. 


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