SC65

P3H4

Identifiers

P3H4, NO55, NOL55, SC65, LEPREL4, prolyl 3-hydroxylase family member 4 (non-enzymatic)

External IDs

MGI: 1913430 HomoloGene: 4713 GeneCards: P3H4

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	No data available	Start	41,801,947 bp^[1]
Band	No data available	End	41,812,604 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	No data available	Start	100,408,456 bp^[2]
Band	No data available	End	100,414,836 bp^[2]

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


10609


66180


ENSG00000141696


ENSMUSG00000006931


Q92791


Q8K2B0

RefSeq (mRNA)


NM_006455


NM_176830

RefSeq (protein)


NP_006446


NP_789800

Location (UCSC)

Chr 17: 41.8 – 41.81 Mb

Chr 17: 100.41 – 100.41 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Synaptonemal complex protein SC65, also known as Leprecan-like protein 4 (LEPREL4) or nucleolar autoantigen No55, is a protein that in humans is encoded by the LEPREL4 gene.^[5]

Function

This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141696 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006931 - Ensembl, May 2017
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
1 2 "Entrez Gene: SC65 synaptonemal complex protein SC65".

Further reading

Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).". J. Proteome Res. 5 (1): 64–75. PMID 16396496. doi:10.1021/pr0502626.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Fosså A, Siebert R, Aasheim HC, et al. (2000). "Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer.". Br. J. Cancer. 83 (6): 743–9. PMC 2363543 . PMID 10952778. doi:10.1054/bjoc.2000.1365.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
Ochs RL, Stein TW, Chan EK, et al. (1996). "cDNA cloning and characterization of a novel nucleolar protein". Mol. Biol. Cell. 7 (7): 1015–24. PMC 275955 . PMID 8862517. doi:10.1091/mbc.7.7.1015.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.

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